o-Anisidine

  • 2-Methoxybenzenamine
  • o-Methoxyaniline
  • 2-Methoxyaniline
  • 2-Aminoanisole
Formula
2-(CH3O)C6H4NH2
Structure
Description
Red or yellow oily liquid with an amine-like odor becomes brownish on exposure to air.
Uses
Intermediate in the manufacturing of dyes, pharmaceuticals, and fragrances.

Registry Numbers and Inventories.
CAS
90-04-0
EC (EINECS/ELINCS)
201-963-1
EC Index Number
612-035-00-4
EC Class
Carcinogenic Category 2; Mutagenic Category 3; Toxic
R 45 68 23/24/25
RTECS
BZ5410000
RTECS class
Tumorigen; Mutagen
UN (DOT)
2431
Merck
13,670
Beilstein/Gmelin
386210
Beilstein Reference
4-13-00-00806
Swiss Giftliste 1
G-1134
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C7H9NO
Formula mass
123.16
Melting point, °C
5
Boiling point, °C
225
Vapor pressure, mmHg
0.09 (25 C)
Vapor density (air=1)
4.25
Saturation Concentration
131.6 ppm (0.013%) at 27 C (calculated)
Critical temperature
455
Critical pressure
42.0
Density
0.966 g/cm3 (13 C)
Solubility in water
Slightly soluble
Viscosity
2.21 cp (55 C)
Surface tension
44.01 g/s2 (20 C)
Refractive index
1.5688 (20 C)
pKa/pKb
9.48 (pKb6
Partition coefficient, pKow
1.18
Heat of vaporization
46.2 kJ/mol
Heat of combustion
-3995 kJ/mol

Hazards and Protection.
Storage
Store in a cool, dry place. Store in a tightly closed container.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Do not get on skin or in eyes. Do not ingest or inhale.
Protection
Eyes: Wear safety glasses and chemical goggles if splashing is possible. Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Wear appropriate gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions. Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container.
Disposal code
9
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen.

Fire.
Flash Point,°C
100
Autoignition, °C
437
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.
Fire potential
This chemical is combustible.
Hazards
When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.
Health
2
 
Flammability
1
 
 
Reactivity
0
 

Health.
Exposure limit(s)
NIOSH REL: Ca 0.5 mg/m3 skin See Appendix A NIOSH IDLH: Potential occupational carcinogen 50 mg/m3
Carcinogin
G-A3, I-2B, CP65
Poison_Class
1*
Exposure effects
May cause cancer according to animal studies.
   Ingestion
May cause irritation of the digestive tract. May cause kidney damage. May cause methemoglobinemia, cyanosis, convulsions, and death. Methemoglobinemia is characterized by dizziness, drowsiness, headache, breath shortness, cyanosis with bluish skin, rapid heart rate and chocolate-brown colored blood.
   Inhalation
May cause severe allergic respiratory reaction. May cause respiratory tract irritation.
   Skin
May be absorbed through the skin in harmful amounts. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. If absorbed, may cause symptoms similar to those for ingestion.
   Eyes
Causes severe eye irritation.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if symptoms occur.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
2431
Response guide
Hazard class
6.1
Packing Group
III
 
USCG CHRIS Code
ADO
 
HS Code
2922 22 00