Solvents, synthetic-resin manufacture, metal polishes, organic synthesis.
Registry Numbers and Inventories.
Japan ENCS (MITI)
Melting point, °C
Boiling point, °C
Vapor pressure, mmHg
0.8902 g/cm3 (0 C)
Solubility in water
1.4983 (16.1 C)
Partition coefficient, pKow
Hazards and Protection.
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry,well-ventilated area away from incompatible substances.
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Wear appropriate protective gloves, clothing and goggles.
Wear positive pressure self-contained breathing apparatus (SCBA).
Make no contact with the spilled material. ELIMINATE all ignition sources and ground all equipment. Stop leak if you can do it without risk. A vapor suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean non-sparking tools to collect absorbed material.
Reacts with oxidizers. Attacks rubber.
When heated to decomposition it emits acrid smoke and fumes.
Upper exp. limit, %
Lower exp. limit, %
Use of water spray when fighting fire may be inefficient. Small Fires: Dry chemical, carbon dioxide, water spray or regular foam. Large Fires: Water spray, fog or regular foam. Do not use straight streams.
HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames.
Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers.
Fire will produce irritating, corrosive and/or toxic gases.
Multiple physical deformities, with signs similar to fetal alcohol syndrome, microencephaly, CNS dysfunction, and variable growth deficiencies have occurred in infants born to mothers who abused toluene during pregnancy.
Ingestion or inhalation may cause vomiting, abdominal cramps, and diarrhea.
Inhalation may cause irritation, acute bronchitis, bronchospasm, pulmonary edema, pneumonitis, and asphyxia. Chronic abusers may develop respiratory failure.
Prolonged contact may cause drying and defatting or superficial burns.
Blepharospasm, inflammation of the eye, corneal edema, and corneal abrasions usually resolve over 1-2 days.
Emesis - vomiting is not indicated due to the possibility for aspiration of gastric contents. Aspiration of gastric contents with a small, flexible nasogastric tube may be indicated when the patient has ingested a large quantity of toluene, or there is a large amount of benzene contamination. The potential toxicity of the amount ingested must be weighed against the substantial risk of aspiration. Activated charcoal: administer charcoal as a slurry (240 ml water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents. Monitor fluid and electrolyte status carefully. Correct hypokalemia with intravenous potassium. Monitor patient for respiratory distress. Monitor ekg and vital signs regularly. Use epinephrine cautiously if indicated. Chronic exposure - evaluate renal and liver function.
Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with beta2 agonist and corticosteroid aerosols.
Remove contaminated clothing and wash exposed area thoroughly with soap and water. A physician should examine the area if irritation or pain persists.
Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.