o-Methoxyphenol

  • anastil
  • FEMA no 2532
  • Guaiacol
  • o-Guaiacol
  • Guaiastil
  • Guaicol
Formula
C7H8O2
Structure
Description
Colorless to faintly yellowish liquid or white or slightly yellow crystalline mass, darkens on exposure to air or light, characteristic sweet, slightly phenolic odor.
Uses
Local anesthetic agent.

Registry Numbers and Inventories.
CAS
90-05-1
EC (EINECS/ELINCS)
201-964-7
EC Index Number
604-031-00-6
EC Class
Harmful; Irritant
R 22 36/38
RTECS
SL7525000
RTECS class
Mutagen; Human Data; Primary Irritant
UN (DOT)
2430
Merck
13,4568
Beilstein/Gmelin
508112
Beilstein Reference
4-06-00-05563
EPA OPP
25005
Swiss Giftliste 1
G-1670
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C7H8O2
Formula mass
124.14
Melting point, °C
28 - 32
Boiling point, °C
205
Vapor pressure, mmHg
0.18 (25 C)
Vapor density (air=1)
4.3
Saturation Concentration
197 ppm (0.02%) at 20 C (calculated)
Critical temperature
427
Critical pressure
48.46
Density
1.1534 g/cm3 (0 C)
Solubility in water
Slightly soluble
Viscosity
4.45 cp (30 C)
Refractive index
1.5429 (20 C)
pKa/pKb
9.97 (pKa)
Partition coefficient, pKow
1.32
Heat of vaporization
45.9 kJ/mol

Hazards and Protection.
Storage
Keep away from sources of ignition. Store in a cool place in the original container and protect from sunlight. Keep under a nitrogen blanket. Store protected from light and air.
Handling
Wash thoroughly after handling. Wash hands before eating. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with skin and eyes. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid ingestion and inhalation. Store protected from light. Store protected from air. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Clean up spills immediately, using the appropriate protective equipment. Scoop up with a nonsparking tool, then place into a suitable container for disposal. Remove all sources of ignition. Provide ventilation.
Disposal code
1
Stability
Stable at room temperature in closed containers under normal storage and handling conditions.
Incompatibilities
Strong oxidizing agents, strong bases, acid chlorides, and acid anhydrides. Darkens upon exposure to light or air, and may decompose.
Decomposition
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Fire.
Flash Point,°C
82
Autoignition, °C
750
Upper exp. limit, %
9.6
Lower exp. limit, %
1.3
Fire fighting
Fires involving this material should be controlled using a dry chemical, carbon dioxide or Halon extinguisher.
Fire potential
This chemical is combustible.
Hazards
When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.

Health.
Poison_Class
3
Exposure effects
May cause fetal effects.
   Ingestion
Causes gastrointestinal irritation with nausea, vomiting and diarrhea. May cause systemic toxicity with acidosis. May be harmful if swallowed.
   Inhalation
Causes respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
   Skin
Causes skin irritation.
   Eyes
Causes severe eye irritation.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
   Skin
Get medical aid. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
2430
Response guide
Hazard class
8
Packing Group
I; II; III
 
21. Phenols. Cresols
HS Code
2909 50 10