o-Phenylenediamine

  • 1,2-Diaminobenzene
Formula
1,2-(NH2)2C6H4
Structure
Description
Colorless monoclinic crystals, darkens in air.
Uses
Manufacture of dyes, photographic developing agent, organic synthesis, laboratory reagent.

Registry Numbers and Inventories.
CAS
95-54-5
EC (EINECS/ELINCS)
202-430-6
EC Index Number
612-145-00-2
EC Class
Carcinogenic Category 3; Mutagenic Category 3; Toxic; Harmful; Irritant; Sensitising; Dangerous for the Environment
R 20/21 25 36 40 43 50/53 68
S 28 36/37 45 60 61
RTECS
SS7875000
RTECS class
Mutagen
UN (DOT)
1673
Merck
12,7438
Beilstein/Gmelin
606074
Beilstein Reference
4-13-00-00038
Swiss Giftliste 1
G-8579
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C6H8N2
Formula mass
108.14
Melting point, °C
103
Boiling point, °C
257
Vapor pressure, mmHg
0.015 (25 C)
Density
1.21 g/cm3
Solubility in water
54 g/L
pKa/pKb
9.54 (pKb)
Partition coefficient, pKow
0.15
Heat of fusion
18.6 kJ/mol
Heat of vaporization
45.5 kJ/mol
Heat of combustion
-3511 kJ/mol

Hazards and Protection.
Storage
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling
Wash thoroughly after handling. Minimize dust generation and accumulation. Avoid contact with skin and eyes. Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Wash clothing before reuse.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear a chemical apron. Wear appropriate clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation.
Disposal code
9
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Nitrogen oxides, carbon monoxide, carbon dioxide.

Fire.
Flash Point,°C
110
Autoignition, °C
540
Upper exp. limit, %
9.8
Lower exp. limit, %
1.5
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Containers may explode when heated. Combustible material; may burn but does not ignite readily. Extinguishing media: For small fires, use dry chemical, carbon dioxide, or water spray. For large fires, use dry chemical, carbon dioxide, alcohol-resistant foam, or water spray. Cool containers with flooding quantities of water until well after fire is out.
Fire potential
This material is probably combustible.
Hazards
When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.
Health
3
 
Flammability
1
 
 
Reactivity
0
 

Health.
Exposure limit(s)
0.1 mg/m3 TLV
Carcinogin
G-A3, CP65
Poison_Class
3
Exposure effects
Prolonged or repeated skin contact may cause dermatitis. May cause methemoglobinemia, which is characterized by chocolate-brown colored blood, headache, weakness, dizziness, breath shortness, cyanosis, rapid heart rate, unconsciousness and possible death.
   Ingestion
May cause irritation of the digestive tract. May cause liver and kidney damage. Methemoglobinemia is characterized by dizziness, drowsiness, headache, breath shortness, cyanosis with bluish skin, rapid heart rate and chocolate-brown colored blood. May be harmful if swallowed. Overexposure may cause methemoglobinemia.
   Inhalation
Dust is irritating to the respiratory tract. Methemoglobinemia is characterized by dizziness, drowsiness, headache, breath shortness, cyanosis with bluish skin, rapid heart rate and chocolate-brown blood. Inhalation of aniline causes anoxia due to the formation of methemoglobinemia.
   Skin
May cause skin irritation. May be absorbed through the skin in harmful amounts.
   Eyes
May cause eye irritation. May result in corneal injury.

First aid
 
   Ingestion
Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid. Wash mouth out with water.
   Inhalation
Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear. DO NOT use mouth-to-mouth respiration.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.
UN number
1673
Response guide
Hazard class
6.1
Packing Group
III
 
9. Aromatic amines
HS Code
2921 51 19