o-Toluenesulfonamide

  • o-Methylbenzenesulfonamide
  • 2-Methylbenzenesulfonamide
  • Toluene-2-sulfonamide
Formula
C7H9NO2S
Structure
Description
Octahedral crystals from alc, prisms from water.
Uses
Ortho- & para-toluenesulfonamide mixt is used as a reactive plasticizer.

Registry Numbers and Inventories.
CAS
88-19-7
EC (EINECS/ELINCS)
201-808-8
R 40 36/37/38
S 26 36/37/39
RTECS
XT4900000
RTECS class
Tumorigen; Mutagen; Reproductive Effector; Primary Irritant
Beilstein/Gmelin
1102362
Beilstein Reference
4-11-00-00229
Swiss Giftliste 1
G-9046
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C7H9NO2S
Formula mass
171.23
Melting point, °C
155 - 156
Boiling point, °C
330
Vapor pressure, mmHg
0.00017 (25 C)
Solubility in water
Slightly soluble
pKa/pKb
10.17 (pKa)
Partition coefficient, pKow
0.84
Heat of vaporization
57.3 kJ/mol

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability
No data.
Incompatibilities
Strong oxidizing agents.

Fire.
Flash Point,°C
178
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Poison_Class
2
Exposure effects
headache, depression, and hallucinations have been reported with therapeutic use of sulfonamides. Coma and seizures were reported following a large overdose of sulfasalazine in one patient. Tremor occurred in one patient following a fixed-dose combination of trimethoprim/sulfamethoxazole.
   Ingestion
Nausea and vomiting are likely to occur.
   Skin
Various dermatological reactions, including rash, pruritus, erythema nodosum, and quite severe and often fatal erythema multiforme of the stevens-johnson type have been reported. This serious reaction has been reported even with the use of ophthalmic preparations. Rashes and fever appear ten days after initiation of therapy and reoccur immediately upon additional courses of the therapy.

First aid
 
   Ingestion
The possible benefit of early removal of some ingested material by cautious gastric lavage must be weighed against potential complications of bleeding or perforation. Activated charcoal activated charcoal binds most toxic agents and can decrease their systemic absorption if administered soon after ingestion. Activated charcoal: administer charcoal as a slurry (240 ml water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents.
   Inhalation
Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with beta2 agonist and corticosteroid aerosols.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.

Transport.