Octahedral crystals from alc, prisms from water.
Ortho- & para-toluenesulfonamide mixt is used as a reactive plasticizer.
Registry Numbers and Inventories.
R 40 36/37/38
S 26 36/37/39
Tumorigen; Mutagen; Reproductive Effector; Primary Irritant
Swiss Giftliste 1
Japan ENCS (MITI)
Melting point, °C
155 - 156
Boiling point, °C
Vapor pressure, mmHg
0.00017 (25 C)
Solubility in water
Partition coefficient, pKow
Heat of vaporization
Hazards and Protection.
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Strong oxidizing agents.
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.
headache, depression, and hallucinations have been reported with therapeutic use of sulfonamides. Coma and seizures were reported following a large overdose of sulfasalazine in one patient. Tremor occurred in one patient following a fixed-dose combination of trimethoprim/sulfamethoxazole.
Nausea and vomiting are likely to occur.
Various dermatological reactions, including rash, pruritus, erythema nodosum, and quite severe and often fatal erythema multiforme of the stevens-johnson type have been reported. This serious reaction has been reported even with the use of ophthalmic preparations. Rashes and fever appear ten days after initiation of therapy and reoccur immediately upon additional courses of the therapy.
The possible benefit of early removal of some ingested material by cautious gastric lavage must be weighed against potential complications of bleeding or perforation. Activated charcoal activated charcoal binds most toxic agents and can decrease their systemic absorption if administered soon after ingestion. Activated charcoal: administer charcoal as a slurry (240 ml water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents.
Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with beta2 agonist and corticosteroid aerosols.
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.