o-Tosyl chloride

  • o-Toluenesulfonyl chloride
  • 2-Methylbenzenesulfonyl chloride
Formula
C7H7ClO2S
Structure
Description
Oily liquid
Uses
Intermediate used in the synthesis of dyes and saccharin.

Registry Numbers and Inventories.
CAS
133-59-5
EC (EINECS/ELINCS)
205-113-0
26 36/37/39 45
UN (DOT)
3265
Beilstein/Gmelin
973180
Beilstein Reference
4-10-00-00229
Canada DSL/NDSL
NDSL
US TSCA
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C7H7ClO2S
Formula mass
190.65
Melting point, °C
10.2
Boiling point, °C
272
Vapor pressure, mmHg
0.01 (25 C)
Density
1.3383 g/ml (20 C)
Solubility in water
Insoluble
Refractive index
1.5555 (20 C)
Heat of vaporization
49.0 kJ/mol

Hazards and Protection.
Storage
Keep tightly closed.
Protection
Compatible chemical-resistant gloves. Chemical safety goggles. Hand: Faceshield (8-inch minimum).
Respirators
Government approved respirator.
Small spills/leaks
Cover with dry lime or soda ash, pick up, keep in a closed container, and hold for waste disposal. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable at normal temperatures and pressures. Moisture
Incompatibilities
Strong oxidizing agents, Strong bases.
Decomposition
Carbon monoxide, Carbon dioxide, Sulfur oxides, Hydrogen chloride gas.

Fire.
Flash Point,°C
119
Fire fighting
Extinguish using Carbon dioxide, dry chemical powder, or appropriate foam. Unsuitable: Do not use water. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Fire potential
Water hydrolyzes material liberating acidic gas which in contact with metal surfaces can generate flammable and/or explosive hydrogen gas.
Hazards
Emits toxic fumes under fire conditions.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.
Health
3
 
Flammability
1
 
 
Reactivity
1
 

Health.
Exposure effects
Corrosive. Causes burns. Lachrymator. Vesicant.
   Ingestion
Can cause irritation or burns of the esophogus or GI tract.
   Inhalation
Can cause sever respiratory tract irritation can progress to ARDS/acute lung injury which may be delayed in onset for up to 24 to 72 hours in some cases. Burns of the esophagus are also possible.C
   Skin
Causes irritation
   Eyes
Causes irritation

First aid
 
   Ingestion
Consider gastric lavage after ingestion of a potentially life-threatening amount of poison if it can be performed soon after ingestion (generally within 1 hour). Protect airway by placement in Trendelenburg and left lateral decubitus position or by endotracheal intubation. Control any seizures first. The use of activated charcole or dilution with milk or water may also be of benefit.
   Inhalation
Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with inhaled beta2 agonist and oral or parenteral corticosteroids.
   Skin
Remove contaminated clothing and wash exposed area thoroughly with soap and water. A physician may need to examine the area if irritation or pain persists.
   Eyes
Irrigate exposed eyes with copious amounts of room temperature water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.

Transport.
UN number
3265
Response guide
Hazard class
8
Packing Group
II