Pancuronium bromide

  • Pavulon
  • Mioblock
  • 2b,16b-Dipiperidino-5a-androstane-3a,17b-diol diacetate dimethobromide
  • Piperidinium, 1,1'-[(2b,3a,5a,16b,17b)-3,17-bis(acetyloxy)androstane-2,16-diyl]bis[1-methyl-, dibromide
Formula
C35H60Br2N2O4
Structure
Description
White to near-white, hydroscopic crystalline powder with no odor.
Uses
Medication.

Registry Numbers and Inventories.
CAS
15500-66-0
EC (EINECS/ELINCS)
239-532-5
RTECS
TN4930000
RTECS class
Drug; Mutagen; Reproductive Effector; Human Data
Merck
12,7139
Beilstein/Gmelin
4121757
Beilstein Reference
5-20-03-00259
Korea ECL
Listed

Properties.
Formula
C35H60N2O4*2Br
Formula mass
732.68
Melting point, °C
214 - 217

Hazards and Protection.
Storage
Pancuronium bromide should be stored under refrigeration at 2-8C. Keep container tightly closed.
Handling
When protective clothing and respirator when handling this material.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant (rubber) gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
A supplied (purified) air respirator, hood fit type, breathable air via hose.
Small spills/leaks
Sweep up carefully and transfer to a container and tightly seal. Wear protective equipment.
Stability
Stable at normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Hydrogen bromide.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
paralysis of skeletal muscle results in heaviness of the eyelids, difficulty in swallowing and talking, diplopia, progressive weakness of the extremities, the neck, intercostals and diaphragm. Tubocurarine does not penetrate the blood brain barrier hence few CNS effects are noted.
   Ingestion
Prolonged apnea and respiratory arrest may be noted due to paralysis of the intercostal muscles and diaphragm.
   Inhalation
Prolonged apnea and respiratory arrest may be noted due to paralysis of the intercostal muscles and diaphragm.
   Skin
Absorbed through wonds and skin defects. Paralysis with risk of respiratory failure.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.