Pantothenic acid

  • (D)-(+)-Pantothenic acid
  • Vitamin B3
  • Vitamin B5
  • Chick antidermatitis factor
  • D(+)-N-(2,4-Dihydroxy-3,3-dimethylbutyryl)-b-alanine
  • b-Alanine, N-[(2R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl]-
Formula
C9H17NO5
Structure
Description
Yellow viscous oil.
Uses
Therap cat: vitamin.

Registry Numbers and Inventories.
CAS
79-83-4
EC (EINECS/ELINCS)
201-229-0
RTECS
RU4729000
RTECS class
Other
Merck
12,7147
Beilstein/Gmelin
1727064
Beilstein Reference
4-04-00-02569
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C9H17NO5
Formula mass
219.24
Melting point, °C
354
Boiling point, °C
449
Solubility in water
Freely soluble
pKa/pKb
4.30 (pKa)
Partition coefficient, pKow
-1.01

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability
Unstable; easily destroyed by acids, bases, heat reasonably stable to air and light; solution most stable between pH 5 and 7 calcium salt pantothenoic acid occurs as an unstable, hygroscopic, viscous oil which is freely soluble in water.
Incompatibilities
Strong oxidizing agents.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
   Ingestion
Nausea, vomiting, abdominal pain, and diarrhea are common, especially following ingestion of multiple vitamins with iron (see iron management).

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.