Papaverine hydrochloride

  • 1-(3,4-Dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride
  • 6,7,3',4'-Tetramethoxy-1-benzylisoquinoline hydrochloride
  • 6,7-Dimethoxy-1-veratrylisoquinoline hydrochloride
  • Cardiospan
  • Papaverine hydrochloride
  • Vasospan
Formula
C20H21NO4.ClH
Structure
Description
White crystalline powder.
Uses
Vasodilaor. Improves blood circulation. Approved to treat erectile dysfunction.

Registry Numbers and Inventories.
CAS
61-25-6
EC (EINECS/ELINCS)
200-502-1
RTECS
NW8575000
RTECS class
Drug; Mutagen; Reproductive Effector; Human Data
UN (DOT)
2811
Beilstein/Gmelin
3921435
Beilstein Reference
5-21-06-00182
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C20H21NO4*ClH
Formula mass
375.88
Melting point, °C
220-225
Density
1.312 g/cm3
Solubility in water
Freely soluble

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Wear appropriate safety goggles, protective clothing and gloves.
Respirators
Wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter.
Small spills/leaks
If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a strong soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Sensitive to light.
Decomposition
Upon decomposition, this material can produce hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide, and nitrogen.

Fire.
Fire fighting
Fires involving this compound should be controlled with a dry chemical, carbon dioxide or halon extinguisher.
Fire potential
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.
Hazards
Contact with metals may evolve flammable hydrogen gas.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.

Health.
Exposure effects
   Ingestion
See Inhalation.
   Inhalation
TOXIC; inhalation, ingestion, or skin contact with material may cause severe injury or death. Effects of contact or inhalation may be delayed.
   Skin
Contact with molten substance may cause severe burns to skin and eyes. See Inhalation.
   Eyes
See Inhalation.

First aid
 
   Ingestion
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician.
   Inhalation
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
   Skin
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
   Eyes
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Transport.
UN number
2811
Response guide
Hazard class
6.1
Packing Group
I; II; III