Papaverine

  • 6,7-Dimethoxy-1-veratrylisoquinoline
  • 6,7-Dimethoxy-1-(3,4-dimethoxybenzyl)isoquinoline
  • Isoquinoline, 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-
Formula
C20H21NO4
Structure
Description
Triboluminescent, orthorhombic prisms from alcohol plus ether.
Uses
Medication (vet).

Registry Numbers and Inventories.
CAS
58-74-2
EC (EINECS/ELINCS)
200-397-2
EC Index Number
614-018-00-7
EC Class
Harmful
RTECS
NW8450000
RTECS class
Drug; Mutagen; Human Data
Merck
12,7151
Beilstein/Gmelin
312930
Beilstein Reference
5-21-06-00182
Austrailia AICS
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C20H21NO4
Formula mass
339.39
Melting point, °C
200 - 201
Boiling point, °C
135-140 (11 torr)
Density
1.308 g/cm3
Solubility in water
Insoluble
Refractive index
1.625 (20 C)
pKa/pKb
7.62 (pKb)

Hazards and Protection.
Storage
Optimal pH for storage of papaverinesolution: 2.0-2.8.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability
Sensitive to light and moisture.
Incompatibilities
Strong oxidizing agents.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
Rapid heart rate and abnormally low blood pressure are common; low heart rate may occur. Both hyperpnea and apnea have been reported after rapid iv injection. lethargy and coma may occur. Dizziness and syncope have been reported following therapeutic use.
   Ingestion
Nausea, vomiting, abdominal pain.
   Inhalation
Hyperpnea, apnea, and respiratory alkalosis may occur.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.