Pargylamine

  • Pargyline
  • Eudatin
  • Supirdyl
  • N-Methyl-N-benzylpropynylamine
  • N-Methyl-N-propargylbenzylamine
  • N-Methyl-N-2-propynylbenzenemethanamine
Formula
C11H13N
Structure
Description
Clear yellow liquid.

Registry Numbers and Inventories.
CAS
555-57-7
EC (EINECS/ELINCS)
209-101-6
RTECS
DP6475000
RTECS class
Drug; Reproductive Effector; Human Data
UN (DOT)
2810
Merck
12,7172
Beilstein/Gmelin
1938132
Beilstein Reference
2-12-00-00548

Properties.
Formula
C11H13N
Formula mass
159.23
Melting point, °C
15 - 20
Boiling point, °C
228
Vapor pressure, mmHg
0.074 (25 C)
Vapor density (air=1)
5.49
Density
1.0291 g/cm3
Solubility in water
Insoluble
Refractive index
1.5224 (23 C)
pKa/pKb
7.50 (pKb)
Partition coefficient, pKow
2.46
Heat of vaporization
46.5 kJ/mol

Hazards and Protection.
Storage
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Do not ingest or inhale. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Clean up spills immediately, using the appropriate protective equipment. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Acid anhydrides, acid chlorides, acids, chloroformates, strong oxidizing agents.
Decomposition
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.

Fire.
Flash Point,°C
83
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Water may be ineffective. Material is lighter than water and a fire may be spread by the use of water. Combustible Liquid. Extinguishing media: Use water spray to cool fire-exposed containers. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Fire potential
Combustible material: may burn but does not ignite readily.
Hazards
When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.
Health
2
 
Flammability
2
 
 
Reactivity
0
 

Health.
Exposure effects
Prolonged or repeated skin contact may cause dermatitis. Effects may be delayed. May cause reproductive effects.
   Ingestion
Harmful if swallowed. May cause gastrointestinal irritation with nausea, vomiting and diarrhea.
   Inhalation
Causes respiratory tract irritation. Can produce delayed pulmonary edema. Inhalation at high concentrations may cause CNS depression and asphixiation.
   Skin
Causes skin irritation. May cause cyanosis of the extremities.
   Eyes
Causes eye irritation. May cause chemical conjunctivitis and corneal damage.

First aid
 
   Ingestion
Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.
UN number
2810
Response guide
Hazard class
6.1
Packing Group
I; II; III