Parthenolide

  • 4,5-alpha-Epoxy-6-beta-hydroxygermacra-1(10),11(13)-dien-12-oic acid gamma-lactone
  • Germacra-1(10),11(13)-dien-12-oic acid, 4,5-alpha-epoxy-6-beta-hydroxy-, gamma-lactone
Formula
C15H20O3
Uses
A sesquiterpene lactone with anti-inflammatory, antisecretory, and spasmolytic properties. Inhibits the expression of COX-2 and proinflammatory cytokines (TNF- and IL-1) in LPS-stimulated macrophages. Also inhibits NF- B and activation of MAP kinase.

Registry Numbers and Inventories.
CAS
20554-84-1
RTECS
LY4220000
Merck
12,7180
New Zealand
Listed

Properties.
Formula
C15H20O3
Formula mass
248.32
Melting point, °C
115-116
Boiling point, °C
394
Vapor pressure, mmHg
2.0E-6 (25 C)
Density
1.13 g/cm3 (20 C)
Solubility in water
Insoluble
Partition coefficient, pKow
2.42
Heat of vaporization
64.4 kJ/mol

Hazards and Protection.
Storage
Freezer (-20 C). Protect from light.
Stability
This product is stable for 2 years as supplied.

Fire.
Flash Point,°C
166

Health.
Exposure effects

First aid
 

Transport.