Pentazocine

  • 2-(3,3-Dimethylallyl)cyclazocine
  • 2-Dimethylallyl-5,9-dimethyl-2'-hydroxybenzomorphan
  • 2-(3,3-dimethylallyl)-2',2'-Hydroxy-5,9-dimethyl-6,7-Benzomorphan
  • Fortalgesic
  • Fortalin
  • Fortral
Formula
C19H27NO
Structure
Description
White to very pale tan crystalline powder. Odorless or almost odorless.
Uses
Medication.

Registry Numbers and Inventories.
CAS
359-83-1
EC (EINECS/ELINCS)
206-634-6
RTECS
PB8750000
RTECS class
Drug; Reproductive Effector; Human Data
Merck
12,7261
Beilstein/Gmelin
1433759
Japan ENCS (MITI)
Listed

Properties.
Formula
C19H27NO
Formula mass
285.43
Melting point, °C
146 - 148
Solubility in water
1 g in greater than 1000 ml
pKa/pKb
8.95 (pKa)
Partition coefficient, pKow
3.31

Hazards and Protection.
Storage
Store in a cool, dry locattion. Protect from light.
Handling
Avoid direct contact with eyes, skin and clothing. Keep out of reach of children. Use only as directed.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Not required.
Small spills/leaks
Provide adequate ventilation and personal protective equipment. Vacuum or scoop up material and place in a container for disposal.
Stability
Stable at normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
No data.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
Central nervous system depression, seizures, and hypotonia have been seen in overdose. With therapeutic use - central nervous system effects reported with pentazocine include dizziness, light-headedness, headache, and infrequently, weakness, seizures, alteration of mood, insomnia, syncope, and very rarely, tremor, irritability, excitement, tinnitus, and faintness. Use of pentazocine may produce CNS depression in the newborn infant.
   Ingestion
See ingestion.
   Inhalation
Nausea, dizziness, light headedness, vomiting euphoria.
   Skin
Irritation. Allergic reaction.
   Eyes
See skin.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.