Pentobarbital

  • Barpental
  • Ethaminal
  • 5-Ethyl-5-(1-methylbutyl)barbituric acid
  • 5-Ethyl-5-(1-methylbutyl)malonylurea
  • 5-Ethyl-5-(Sec-Pentyl)barbituric acid
  • Mebubarbital
Formula
C11H18N2O3
Structure
Description
White to practically white, fine, powder. Practically odorless.
Uses
This is a drug of abuse.

Registry Numbers and Inventories.
CAS
76-74-4
EC (EINECS/ELINCS)
200-983-8
RTECS
CQ5775000
RTECS class
Drug; Reproductive Effector; Human Data
Merck
12,7272
Beilstein/Gmelin
87067
Beilstein Reference
5-24-09-00168
Austrailia AICS
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C11H18N2O3
Formula mass
226.28
Melting point, °C
129-130
Boiling point, °C
506
Solubility in water
Insoluble
pKa/pKb
7.88 (pKa)
Partition coefficient, pKow
2.10
Heat of fusion
21.3 kJ/mol

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability
Aq solution of pentobarbital sodium are not Pentobarbital sodium sensitive to air and moisture pentobarbital sodium alkaline solution decomp on storage and heating.
Incompatibilities
Strong oxidizing agents.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
CNS findings range from drowsiness to deep coma. Seizures are not expected, except upon withdrawal from barbiturate dependence.
   Ingestion
Respiratory arrest may occur following severe intoxication. Aspiration pneumonia has been reported, in barbiturate ingestions, following vomiting of gastric contents.
   Inhalation
Respiratory arrest may occur following severe intoxication. Aspiration pneumonia has been reported, in barbiturate ingestions, following vomiting of gastric contents.
   Skin
Erythematous or hemorrhagic blisters (barb - burns) may occasionally occur on the hands, buttocks, in between the knees, and at any pressure point.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.