Pentoxifylline

  • Pentoxiphylline
  • Dimethyloxohexylxanthine
  • Torental
  • Agapurin Retard
  • 3,7-Dimethyl-1-(5-oxohexyl)-1H,3H-purin-2,6-dione
  • 3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione
Formula
C13H18N4O3
Structure
Description
White powder.
Uses
Used to improve blood flow in patients with circulation problems to reduce aching, cramping, and tiredness in the hands and feet.

Registry Numbers and Inventories.
CAS
6493-05-6
EC (EINECS/ELINCS)
229-374-5
RTECS
XH2475000
RTECS class
Drug; Mutagen; Reproductive Effector; Human Data
Merck
12,7278
Beilstein/Gmelin
558929
Beilstein Reference
5-26-14-00081
Austrailia AICS
Listed
Korea ECL
Listed

Properties.
Formula
C13H18N4O3
Formula mass
278.31
Melting point, °C
105
Boiling point, °C
460
Solubility in water
Slightly soluble
pKa/pKb
12.74 (pKb)

Hazards and Protection.
Storage
Store in a cool, dry place. Store in a tightly closed container.
Handling
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Protection
Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container.
Stability
No data.
Incompatibilities
Strong oxidizing agents.
Decomposition
Nitrogen oxides, carbon monoxide, carbon dioxide.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.

Health.
Exposure effects
   Ingestion
Harmful if swallowed.
   Inhalation
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
   Skin
May cause skin irritation.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
Get medical aid immediately. Wash mouth out with water.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.