Crystals. Almost odorless.
Registry Numbers and Inventories.
Drug; Mutagen; Reproductive Effector; Human Data
Japan ENCS (MITI)
Melting point, °C
175 - 176
Boiling point, °C
240 - 244 (0.1 torr)
Solubility in water
28.3 mg/L @ 24 C
Partition coefficient, pKow
Hazards and Protection.
Perphenazine should be stored at room temperature and protected from temperatures above 40C and from freezing. Should be protected from light.
Train employees concering hazards and precautions. Change respirator cartridge after 4 hours of continous use or upon detection of an odor..
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Half mask respirator with organic vapor/acid gas/high efficency cartridges.
Minimize contact with material and keep others away from clean up area. Wear appropriate protective equipment. Scoop, absorb or vacuum to pick up material. Clean area with an alkaline cleaner and detergent.
Sensitive to light.
Strong oxidizing agents.
Oxides of carbon.
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.
Phenothiazines may interfere with the body's ability to thermoregulate, and cause elevated body temperature or reduced body temperature. Abnormally low blood pressure and elevated blood pressure have both been reported; abnormally low blood pressure is the more common serious effect. CNS depression, coma, agitation, extrapyramidal signs, and seizures may occur with overdose. Neuroleptic malignant syndrome has rarely occurred with therapeutic use and overdose. Most phenothiazines are rated pregnancy category C and should be used only when potential therapeutic benefit outweighs potential effects on the fetus.
Gastrointestinal abnormalities, especially constipation with possible obstruction, may occur with phenothiazine overdose.
Respiratory depression, pulmonary edema, and a loss of the gag reflex with possible aspiration may occur with phenothiazine overdose.
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.