Perphenazine

  • Chlorpiprazine
  • Decentan
  • Emesinal
Formula
C21H26ClN3OS
Structure
Description
Crystals. Almost odorless.
Uses
Medication (vet).

Registry Numbers and Inventories.
CAS
58-39-9
EC (EINECS/ELINCS)
200-381-5
RTECS
TL7175000
RTECS class
Drug; Mutagen; Reproductive Effector; Human Data
Merck
12,7323
Beilstein/Gmelin
54730
Beilstein Reference
4-27-00-01307
Austrailia AICS
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C21H26ClN3OS
Formula mass
403.98
Melting point, °C
175 - 176
Boiling point, °C
240 - 244 (0.1 torr)
Solubility in water
28.3 mg/L @ 24 C
Partition coefficient, pKow
4.20

Hazards and Protection.
Storage
Perphenazine should be stored at room temperature and protected from temperatures above 40C and from freezing. Should be protected from light.
Handling
Train employees concering hazards and precautions. Change respirator cartridge after 4 hours of continous use or upon detection of an odor..
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Half mask respirator with organic vapor/acid gas/high efficency cartridges.
Small spills/leaks
Minimize contact with material and keep others away from clean up area. Wear appropriate protective equipment. Scoop, absorb or vacuum to pick up material. Clean area with an alkaline cleaner and detergent.
Stability
Sensitive to light.
Incompatibilities
Strong oxidizing agents.
Decomposition
Oxides of carbon.

Fire.
Flash Point,°C
>100
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
Phenothiazines may interfere with the body's ability to thermoregulate, and cause elevated body temperature or reduced body temperature. Abnormally low blood pressure and elevated blood pressure have both been reported; abnormally low blood pressure is the more common serious effect. CNS depression, coma, agitation, extrapyramidal signs, and seizures may occur with overdose. Neuroleptic malignant syndrome has rarely occurred with therapeutic use and overdose. Most phenothiazines are rated pregnancy category C and should be used only when potential therapeutic benefit outweighs potential effects on the fetus.
   Ingestion
Gastrointestinal abnormalities, especially constipation with possible obstruction, may occur with phenothiazine overdose.
   Inhalation
Respiratory depression, pulmonary edema, and a loss of the gag reflex with possible aspiration may occur with phenothiazine overdose.
   Skin
Irritation.
   Eyes
Irritation.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.