Phalloidin

  • Cyclic(l-alanyl-d-threonyl-l-cysteinyl-cis-4-hydroxy-l-prolyl-l-alanyl-2-phalloidine
Formula
C35H48N8O11S
Structure
Description
Lyophilizate.
Uses
Physiological studies.

Registry Numbers and Inventories.
CAS
17466-45-4
EC (EINECS/ELINCS)
241-484-5
RTECS
SE9800000
RTECS class
Mutagen; Natural Product
Merck
12,7336
Beilstein/Gmelin
4347460

Properties.
Formula
C35H48N8O11S
Formula mass
788.88
Melting point, °C
280-282
Solubility in water
Soluble

Hazards and Protection.
Storage
Store in a cool, dry location in a tightly sealed container.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Rubber gloves, safety goggles and lab coat.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Use an absorbent material to contain/pick up the spilled solution. Place in suitable container for later disposal.
Stability
Stable under normal handling and storage conditions.

Fire.
Flash Point,°C
>200
Fire fighting
Wear structural firefighting gear and SCBA. Use extinguishing media most appropriate for surrounding fire.
Health
1
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
Hypovolemic shock may occur during the gastrointestinal phase. Hypoventilation and cardiovascular collapse may accompany severe hepatic failure. neurologic symptoms are related to hepatic failure and may include encephalopathy, somnolence, confusion, coma and seizures. In pregnancy the fetus may develop a toxic hepatitis. Because it is unknown whether amatoxins are excreted in breast milk, nursing should be stopped.
   Ingestion
Gastrointestinal symptoms occur after a latent period and include abdominal pain, vomiting, and watery diarrhea.
   Inhalation
Hypoventilation may occur in patients with hepatic coma. Adult respiratory distress syndrome may develop in the later stages of poisoning.
   Skin
May cause irritation.
   Eyes
May cause irritation.Scleral icterus is associated with jaundice. Epistaxis related to coagulation disorders may occur.

First aid
 
   Ingestion
If any symptoms occur, keep victim warm and clam. Get immediate medical assistance.
   Inhalation
If breathing becomes difficult, remove to fresh air. Seek medical assistance.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Clush with large amounts of water for at least 15 minutes.

Transport.