Phenacetin

  • p-Acetophenetidide
  • 4'-Ethoxyacetanilide
  • 4-Acetophenetidide
  • N-(4-Ethoxyphenyl)acetamide
Formula
C10H13NO2
Structure
Description
Odorless fine white crystalline solid with a lightly bitter taste.
Uses
Analgesic.

Registry Numbers and Inventories.
CAS
62-44-2
EC (EINECS/ELINCS)
200-533-0
RTECS
AM4375000
RTECS class
Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data
Merck
12,7344
Beilstein/Gmelin
1869238
Beilstein Reference
4-13-00-01092
RCRA
U187
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C10H13NO2
Formula mass
179.22
Melting point, °C
134-135
Boiling point, °C
355
Vapor pressure, mmHg
260 (185 C)
Density
1.2404
Solubility in water
800 m8 g/L
Refractive index
1.505 (20 C)
Partition coefficient, pKow
1.58
Heat of fusion
31.3 kJ/mol
Heat of vaporization
60.0 kJ/mol
Heat of combustion
-5455 kJ/mol

Hazards and Protection.
Storage
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling
Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions. Provide ventilation.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents - strong acids - strong bases.
Decomposition
Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen.

Fire.
Flash Point,°C
168
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.

Health.
Carcinogin
I-2A, N-2, CP65
Exposure effects
Chronic ingestion may cause effects similar to those of acute ingestion. Chronic exposure may lead to weight loss, shortness of breath, weakness, and often aplastic anemia. Experimental carcinogen.
   Ingestion
May cause irritation of the digestive tract. May cause kidney damage. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. Methemoglobinemia is characterized by dizziness, drowsiness, headache, breath shortness, cyanosis with bluish skin, rapid heart rate and chocolate-brown colored blood. May cause sideroblastic anemia and hemolytic anemia. May result in Stevens-Johnson syndrome. Ingestion of large amounts may cause cyanosis, respiratory depression and cardiac arrest.
   Inhalation
May cause respiratory tract irritation. May cause methemoglobinemia, cyanosis, convulsions, tachycardia, dyspnea, and death.
   Skin
May cause skin irritation. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. May produce mucosal lesions.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
USCG CHRIS Code
ATE