Phenindione

  • athrombon
  • bindan
  • Cronodione
  • Danedion
  • Danilon
  • Danilone
Formula
C15H10O2
Structure
Description
Leaflets from alcohol. Almost odorless.
Uses
Medication.

Registry Numbers and Inventories.
CAS
83-12-5
EC (EINECS/ELINCS)
201-454-4
RTECS
NK6125000
RTECS class
Drug; Human Data
UN (DOT)
1325
Merck
12,7381
Beilstein/Gmelin
1911699
Beilstein Reference
4-07-00-02570

Properties.
Formula
C15H10O2
Formula mass
222.24
Melting point, °C
149-151
Boiling point, °C
410
Vapor pressure, mmHg
6E-7 (25 C)
Solubility in water
Insoluble
pKa/pKb
7.72 (pKa)
Partition coefficient, pKow
2.75
Heat of vaporization
66.2 kJ/mol

Hazards and Protection.
Storage
Store in a cool, dry place. Keep container closed when not in use.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Protection
Eyes: Wear chemical goggles. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment.
Stability
Stable under normal temperatures and pressures.
Decomposition
Irritating and toxic fumes and gases.

Fire.
Flash Point,°C
153
Autoignition, °C
480
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire.
Fire potential
Flammable/combustible material. May be ignited by friction, heat, sparks or flames.
Combustion products
Fire may produce irritating and/or toxic gases.

Health.
Exposure effects
Intracranial hemorrhage and hematomyelia may occur following warfarin therapy. The use of warfarin during pregnancy has been associated with teratogenic effects. <br>Fetal intraventricular hemorrhage has been reported following maternal ingestion of warfarin. <br>Craniofacial, musculoskeletal, skin, eye, gastrointestinal, and cardiovascular developmental abnormalities have been observed in the offspring of women administered warfarin sodium during pregnancy. <br>Intrauterine fetal demise, intrauterine growth retardation, and hemorrhagic disease of the newborn have been reported following administration of warfarin sodium to pregnant women.
   Ingestion
Abdominal pain, vomiting, gastrointestinal bleeding, hemoptysis, and bloody or melenotic stools may occur.
   Skin
Warfarin may be absorbed through the skin and cause systemic poisoning.
   Eyes
See Skin.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid immediately.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Remove contaminated clothing and shoes.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
1325
Response guide
Hazard class
4.1
Packing Group
II; III