Phenmetrazine

  • Psychamine A 66
  • Oxazimedrine
  • 3-Methyl-2-phenylmorpholine
  • 3-Methyl-2-phenyltetrahydro-2H-1,4-oxazine
  • Dl-2-phenyl-3-methyltetrahydro-1,4-oxazine
  • 2-Phenyl-3-methyltetrahydro-1,4-oxazine
Formula
C11H15NO
Structure
Description
Liquid.
Uses
Phenmetrazine hydrochloride is no longer commercially available in the usa. Phenmetrazine hydrochloride.

Registry Numbers and Inventories.
CAS
134-49-6
EC (EINECS/ELINCS)
205-143-4
RTECS
QE6475000
RTECS class
Human Data
Merck
12,7385
Beilstein/Gmelin
140490
Beilstein Reference
4-27-00-01050
Austrailia AICS
Listed

Properties.
Formula
C11H15NO
Formula mass
177.25
Melting point, °C
178
Boiling point, °C
83 - 85 (0.6 torr)
Solubility in water
Very soluble
pKa/pKb
8.58 (pKa)

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability
No data.
Incompatibilities
Strong oxidizing agents.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
Severe elevated body temperature may develop. Elevated blood pressure and rapid heart rate are common. Agitation, confusion, paranoia, delirium, hallucinations, restlessness, hyperactivity, talkativeness, irritability, insomnia, and headache are common. Chorea, dystonia, fasciculations, muscle rigidity, tics, and tremors may develop. Seizures and coma may occur with severe intoxication. Other neurological effects have included stroke and cerebral vasculitis. Serotonin syndrome has occurred.
   Ingestion
Vomiting, diarrhea, cramps, anorexia and gastrointestinal hemorrhage may occur.
   Inhalation
Tachypnea is common. Pulmonary hypertension has been associated with chronic use or abuse which may result from contaminants. Pulmonary edema and ards are unusual complications of severe exposure.
   Skin
The skin is usually flushed and diaphoretic.

First aid
 
   Ingestion
Do not induce emesis. Activated charcoal: administer charcoal as a slurry (240 ml water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.