Phenothiazine

  • Thiodiphenylamine
  • Dibenzothiazine
Formula
C12H9NS
Structure
Description
Greyish-green to greenish-yellow solid, slight odor.
Uses
Manufacture of dyes, parent compound for chlorpromazine & related antipsychotic drugs, polymerization inhibitor, antioxidant.

Registry Numbers and Inventories.
CAS
92-84-2
EC (EINECS/ELINCS)
202-196-5
R 52/53
RTECS
SN5075000
RTECS class
Agricultural Chemical and Pesticide; Drug; Mutagen; Reproductive Effector; Human Data
UN (DOT)
3077
Merck
12,7404
Beilstein/Gmelin
143237
Beilstein Reference
4-27-00-01214
EPA OPP
64501
Swiss Giftliste 1
G-2714
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C12H9NS
Formula mass
199.28
Melting point, °C
182 - 185
Boiling point, °C
371
Vapor pressure, mmHg
1E-5 (25 C)
Saturation Concentration
Nearly zero
Density
1.34 g/cm3 (20 C)
Solubility in water
Insoluble
Refractive index
1.6353 (212 C)
pKa/pKb
11.48 (pKb)
Partition coefficient, pKow
4.15
Heat of vaporization
61.8 kJ/mol

Hazards and Protection.
Storage
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Do not store in direct sunlight. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling
Wash thoroughly after handling. Use only in a well ventilated area. Minimize dust generation and accumulation. Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container.
Disposal code
3
Stability
Stable under normal temperatures and pressures. Substance undergoes color change upon exposure to light and air.
Incompatibilities
Strong oxidizing agents - strong acids.
Decomposition
Nitrogen oxides, carbon monoxide, oxides of sulfur, carbon dioxide.

Fire.
Flash Point,°C
202
Autoignition, °C
470
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. This material in sufficient quantity and reduced particle size is capable of creating a dust explosion. Flammable solid. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.
Fire potential
Although phenothiazine oxidizes fairly easily when it is exposed to air, risk of fire is not high.
Combustion products
if involved in fire, phenothiazine produces highly toxic sulfur and nitrogen oxides, which are dangerous lung irritants.
Health
2
 
Flammability
2
 
 
Reactivity
0
 

Health.
Exposure limit(s)
TLV: ppm; 5 mg/m3 (as TWA) (skin) (ACGIH 1996). NIOSH REL: TWA 5 mg/m3 skin
Poison_Class
3
Exposure effects
Chronic inhalation may cause effects similar to those of acute inhalation.
   Ingestion
May cause irritation of the digestive tract.
   Inhalation
Causes respiratory tract irritation. May cause liver and kidney damage. May cause anemia.
   Skin
Causes skin irritation. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. Substance is rapidly absorbed through the skin. May cause dermatitis. Contact with the skin may cause photosensitivity.
   Eyes
Causes eye irritation. May cause painful sensitization to light. Causes redness and pain.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.
UN number
3077
Response guide
HS Code
2934 30 90