Phenoxybenzamine

  • Bensylyte
  • Dibenyline
  • Dibenzyline
  • 688A
  • N-Phenoxyisopropyl-N-benzyl-b-chloroethylamine
  • N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine
Formula
C18H22ClNO
Structure
Description
Crystals from petroleum ether.
Uses
Medication.

Registry Numbers and Inventories.
CAS
59-96-1
EC (EINECS/ELINCS)
200-446-8
RTECS
DP3500000
RTECS class
Tumorigen; Mutagen; Reproductive Effector; Human Data
Merck
12,7409
Beilstein/Gmelin
2129697
Beilstein Reference
4-12-00-02204
Austrailia AICS
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C18H22ClNO
Formula mass
303.83
Melting point, °C
38 - 40
Boiling point, °C
324
Critical temperature
565
Critical pressure
34.8
Solubility in water
Insoluble
pKa/pKb
6.58 (pKa)
Partition coefficient, pKow
2.77

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability
No data.
Incompatibilities
Strong oxidizing agents.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Carcinogin
CP65
Exposure effects
dizziness, CNS stimulation, and seizures may occur. Syncope is a first-dose effect reported with the use of prazosin and terazosin.
   Ingestion
Vomiting, abdominal pain, and diarrhea may occur following large oral doses.
   Skin
Flushing is common. An erythematous rash was reported with terazosin therapy.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.