Phenprocoumarole

  • Marcumar
  • Falithrom
  • Liquamar
  • 3-(1-Phenylpropyl)-4-hydroxycoumarin
  • 4-Hydroxy-2-oxo-3-(1-phenylpropyl)-2H-chromene
  • 4-Hydroxy-3-(1-phenylpropyl)-2H-1-benzopyran-2-one
Formula
C18H16O3
Structure
Description
Fine white crystalline powder. Odorless or has slight odor.
Uses
Medication.

Registry Numbers and Inventories.
CAS
435-97-2
EC (EINECS/ELINCS)
207-108-9
RTECS
GN6769000
RTECS class
Other
Merck
12,7413
Beilstein/Gmelin
1291115
Beilstein Reference
5-18-02-00343

Properties.
Formula
C18H16O3
Formula mass
280.32
Melting point, °C
178
Solubility in water
Insoluble
pKa/pKb
4.50 (pKa)
Partition coefficient, pKow
3.62

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability
No data.
Incompatibilities
Strong oxidizing agents.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
Intracranial hemorrhage and hematomyelia may occur following warfarin therapy. The use of warfarin during pregnancy has been associated with teratogenic effects. <br>Fetal intraventricular hemorrhage has been reported following maternal ingestion of warfarin. <br>Craniofacial, musculoskeletal, skin, eye, gastrointestinal, and cardiovascular developmental abnormalities have been observed in the offspring of women administered warfarin sodium during pregnancy. <br>Intrauterine fetal demise, intrauterine growth retardation, and hemorrhagic disease of the newborn have been reported following administration of warfarin sodium to pregnant women.
   Ingestion
Abdominal pain, vomiting, gastrointestinal bleeding, hemoptysis, and bloody or melenotic stools may occur.
   Skin
Warfarin may be absorbed through the skin and cause systemic poisoning.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.