Phenyl ethyl ketone

  • Ethyl phenyl ketone
  • 1-Phenyl-1-propanone
  • Propionylbenzene
  • Propiophenone
Formula
C9H10O
Structure
Description
Water-white to light amber liq. Strong, persistent, agreeable, flowery odor.
Uses
In perfumery, in synthesis of ephedrine & related compounds.

Registry Numbers and Inventories.
CAS
93-55-0
EC (EINECS/ELINCS)
202-257-6
RTECS
UG7175000
RTECS class
Primary Irritant
UN (DOT)
1224
Merck
12,8015
Beilstein/Gmelin
606215
Beilstein Reference
4-07-00-00680
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C9H10O
Formula mass
134.18
Melting point, °C
18
Boiling point, °C
217
Vapor pressure, mmHg
10 (50 C)
Vapor density (air=1)
4.63
Density
1.157 g/cm3 (0 C)
Solubility in water
Insoluble
Surface tension
37.22 g/s2 (22 C)
Refractive index
1.5274 (20 C)
Partition coefficient, pKow
2.19
Heat of vaporization
45.5 kJ/mol

Hazards and Protection.
Storage
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation. Use with adequate ventilation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Clean up spills immediately, using the appropriate protective equipment. Remove all sources of ignition. Provide ventilation.
Disposal code
1
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents, strong bases.
Decomposition
Carbon monoxide, carbon dioxide.

Fire.
Flash Point,°C
85
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Combustible Liquid. Containers may explode when heated. Extinguishing media: Use water spray to cool fire-exposed containers. In case of fire, use carbon dioxide, dry chemical powder or appropriate foam.
Fire potential
Slight risk when exposed to heat or flame. Can react with oxidizing materials
Hazards
Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.
Health
-
 
Flammability
1
 
 
Reactivity
0
 

Health.
Exposure effects
Limited studies have generally documented little or no effect of ketones on reproduction in experimental animals. Human data is lacking. 2,5-Hexanedione has an effect on spermatogenesis in male experimental animals.
   Ingestion
May cause irritation of the digestive tract.
   Inhalation
Vapors cause irritation of the respiratory system.
   Skin
Causes skin irritation.
   Eyes
Vapors cause eye irritation.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
1224
Response guide
Hazard class
3
Packing Group
I; II; III
 
HS Code
2914 39 00