Phenytoin sodium

  • 5,5-Diphenyhydanthoin sodium
  • Lepitoin sodium
  • Minetoin
  • Sodium diphenylhydantoin
  • Sodium 5,5-diphenyl-2,4-imidazolidinedione
  • 2,4-Imidazolidinedione, 5,5-diphenyl-, monosodium salt
Formula
C15H12N2O2 . Na
Structure
Description
White powder.
Uses
Medication (vet), recommended for epileptic seizures in dogs.

Registry Numbers and Inventories.
CAS
630-93-3
EC (EINECS/ELINCS)
211-148-2
RTECS
MU1400000
RTECS class
Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data
Beilstein/Gmelin
4221969
Canada DSL/NDSL
NDSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Korea ECL
Listed

Properties.
Formula
C15H12N2O2.Na
Formula mass
275.26
Melting point, °C
292-299
Solubility in water
Soluble.
pKa/pKb
8.06 (pKa)

Hazards and Protection.
Storage
Storage location should be close to laboratory where it is to be used, so that only small amounts need to be transported. Carcinogens should be kept in only one section of storage area, explosion-proof refrigerator or freezer as required. The area should be appropriately labeled. An inventory should be kept showing the quantity of carcinogen and date it was acquired. Facilities for dispensing should be contiguous to storage area. Chemical carcinogens store below 40C, preferably between 15 and 30C, unless otherwise specified by manufacturer. Store in a tight container. Protect from freezing.
Handling
Avoid contact. Only used in a chemical hood, while using protective equipment.
Protection
Dispensers of liquid detergent should be available. In the laboratory, gloves and protective clothing should always be worn but should not be assumed to provide full protection. Carefully fitted masks or respirators may be necessary when working with particulates or gases, and disposable plastic aprons might provide additional protection. Protective clothing should be of distinctive color, as a reminder not to be worn outside the laboratory.
Respirators
NIOSH approved respirator.
Small spills/leaks
Evacutae area. Wear approved SCBA, rubber boots and gloves. Sweep up and place in a bag for waste disposal. Avoid reaising dust. Ventilate area. Wash spill site after pickup is complete.
Stability
Sensitive to light phenytoin a slight yellowing of the solution will not affect its potency. After being refrigerated, solution may form a precipitate which usually dissolves after being warmed to room temperature; however, do not use if the solution is not clear.
Incompatibilities
Strong oxidizing agents.
Decomposition
Oxides of carbon and nitrogen.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Carcinogin
CP65
Exposure effects
Cerebellar ataxia, nystagmus, hyperreflexia, drowsiness, lethargy, and coma may occur. Choreoathetosis and dyskinesias have been reported. CNS depression may occur more commonly in children, and ataxia may occur more commonly in adults.
   Ingestion
Harmful fi swallowed. Can cause gastrointestinal disturbances, nausea, slurred speach.
   Inhalation
Nausea, dizziness, headache, ataxia, blurred vision, nystagmus, and mental confusion.
   Skin
Cutaneous eruptions following phenytoin therapy are common. Purple glove syndrome has been reported following intravenous phenytoin.
   Eyes
Irritation.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.