Phytonadione

  • Vitimin K1
Formula
C31H46O2
Structure
Description
Pale yellow, odorless powder.
Uses
Medication (vet).

Registry Numbers and Inventories.
CAS
84-80-0
EC (EINECS/ELINCS)
201-564-2
RTECS
QJ5800000
RTECS class
Tumorigen; Drug; Human Data
UN (DOT)
1224
Merck
12,7536
Beilstein/Gmelin
2568816
Beilstein Reference
4-07-00-02496
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Korea ECL
Listed

Properties.
Formula
C31H46O2
Formula mass
450.71
Melting point, °C
-20
Boiling point, °C
140-145 (0.001 torr)
Density
0.967 g/cm3 (25 C)
Solubility in water
insoluble
Refractive index
1.5263 (20 C)

Hazards and Protection.
Storage
Keep tightly closed in a cool place in a tightly closed container.
Handling
Containers of this material may be hazardous when emptied. Since emptied containers retain product residues (vapor, liquid, and/or solid), all hazard precautions given in the data sheet must be observed. Use good personal hygiene practices. Wash hands before eating, drinking, smoking, or using toilet facilities. Promptly remove soiled clothing and wash before reuse. Shower after work using plenty of soap and water.
Protection
Wear appropriate protective gloves, clothing and goggles.
Respirators
Wear positive pressure self-contained breathing apparatus (SCBA).
Small spills/leaks
Make no contact with the spilled material. ELIMINATE all ignition sources and ground all equipment. Stop leak if you can do it without risk. A vapor suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean non-sparking tools to collect absorbed material.
Stability
Stable to air and moisture, but decomp in sunlight stable in quinone form unaffected by dil acids, destroyed by alkali hydroxides and reducing agents phytonadione is stable to heat and moisture and may be autoclaved.
Incompatibilities
Oxidizing agents.
Decomposition
Carbon dioxide and carbon monoxide.

Fire.
Flash Point,°C
>110
Fire fighting
Use of water spray when fighting fire may be inefficient. Small Fires: Dry chemical, carbon dioxide, water spray or alcohol-resistant foam. Large Fires: Water spray, fog or alcohol-resistant foam. Use water spray or fog; do not use straight streams.
Fire potential
HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames.
Hazards
Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.
Health
1
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
Abnormally low blood pressure may occur precipitously following intravenous injection of phytonadione. Seizures have been rarely reported following intravenous phytonadione injection.
   Ingestion
Transient nausea may occur following injection.
   Inhalation
Dyspnea has been reported after rapid intravenous infusion of phytonadione.
   Skin
Dermatological reactions have included a delayed (generally 1 to 2 weeks) pruritic, erythematous eruption at sites of injection, with occasional persistence of pruritus at affected sites. A chronic progressive scleroderma-like reaction has also been de
   Eyes
See Inhalation.

First aid
 
   Ingestion
Seek medical assistance.
   Inhalation
Move victim to fresh air. Apply artificial respiration if victim is not breathing. Administer oxygen if breathing is difficult.
   Skin
Remove and isolate contaminated clothing and shoes. Wash skin with soap and water. Flush with running water for at least 20 minutes
   Eyes
Flush with running water for at least 20 minutes.

Transport.
UN number
1224
Response guide
Hazard class
3
Packing Group
I; II; III