Picloram

  • 4-Amino-3,5,6-trichloro-2-pyridinecarboxylic acid
  • 4-Amino-3,5,6-trichloropicolinic acid
  • 4-Amino-3,5,6-Trichloropyridine-2-carboxylic acid
Formula
C6H3Cl3N2O2
Structure
Description
Fine beige crystals or white powder. Odor of chlorine.
Uses
Systemic herbicide.

Registry Numbers and Inventories.
CAS
1918-02-1
EC (EINECS/ELINCS)
217-636-1
RTECS
TJ7525000
RTECS class
Agricultural Chemical and Pesticide; Tumorigen; Mutagen; Reproductive Effector
Merck
12,7552
Beilstein/Gmelin
479075
Beilstein Reference
5-22-13-00585
EPA OPP
5101
Swiss Giftliste 1
G-3306
Canada DSL/NDSL
NDSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed

Properties.
Formula
C6H3Cl3N2O2
Formula mass
241.46
Melting point, °C
218 - 219
Boiling point, °C
366
Vapor pressure, mmHg
0.000000616
Solubility in water
400 mg/L
pKa/pKb
3.6 (pKa)
Partition coefficient, pKow
1.89

Hazards and Protection.
Storage
Keep containers closed.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Wear appropriate eye protection and protective clothing to prevent skin and eye contact.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
Stability
Low volatility storage Stability: A minimum of 2 years the expected shelf life of concentrated chemical is approximately three years in aqueous solution, decomposed by UV irradiation.
Incompatibilities
May be sensitive to prolonged exposure to light Incompatible with strong oxidizing agents, strong acids, acid chlorides and acid anhydrides.

Fire.
Fire fighting
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher.
Fire potential
This material is probably combustible.

Health.
Exposure limit(s)
TLV: ppm; 10 mg/m3 (as TWA) (ACGIH 1993-1994). OSHA PEL: TWA 15 mg/m3 (total) TWA 5 mg/m3 (resp) NIOSH REL: See Appendix D
Poison_Class
4
Exposure effects
Although seizures have not been reported in humans, seizures have developed in animals exposed to fatal amounts. No teratogenicity was observed in several studies. However, there are reports that Tordon 202c (a picloram and 2,4-D combination herbicide) showed teratogenesis and fetal growth depression in mice by paternal exposure and combined preconceptional and gestational exposure.
   Ingestion
Nausea is possible after ingestion of massive amounts of picloram.
   Inhalation
Picloram dust is irritating to the respiratory tract.
   Skin
Picloram is mildly irritating to skin.
   Eyes
Eye irritation may occur with exposure to picloram.

First aid
 
   Ingestion
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician.
   Inhalation
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
   Skin
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
   Eyes
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Transport.