(-)-Picrotoxinin

  • Picrotoxinine
  • 3,6-Methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione, hexahydro- 2a-hydroxy-8b-methyl-9-(1-methylethenyl)-, (1aR-(1a-alpha,2a-beta,3-beta,6-beta,6a-beta, 8as*,8b-beta,9R*))
Formula
C15H16O6
Description
White crystalline powder.

Registry Numbers and Inventories.
CAS
17617-45-7
RTECS
PC5150000
Merck
12,7571

Properties.
Formula
C15H16O6
Formula mass
292.29
Melting point, °C
209.5
Boiling point, °C
552
Vapor pressure, mmHg
1.8E-14 (25 C)
Density
1.52 g/cm3 (20 C)
Solubility in water
Insoluble
pKa/pKb
13.24 (pKb)
Partition coefficient, pKow
-0.13
Heat of vaporization
95.6 kJ/mol

Hazards and Protection.
Storage
Store in a tightly sealed container. Protect from light.
Protection
Safety goggles, rubber boots, heavy rubber gloves.
Small spills/leaks
Avoid raising dust. Ventilate area and wash spill site after material pick up is complete. Sweep up or pick up and place in a bag and hold for waste disposal.
Stability
Stable at normal temperatures and pressures.
Incompatibilities
Oxidizing agents, acids, bases.

Fire.
Flash Point,°C
214
Fire fighting
Extinguish with water spray, carbon dioxide, dry chemical powder, alcohol or polymer foam. Wear self-contained breathing apparatus and protective clothing.
Combustion products
Emits toxic fumes under fire conditions.

Health.
Exposure effects
May be fatal if swallowed or absorbed through skin. A powerful CNS stimulant, acting on the mid-brain and motor cortex. This material stimulates the respiratory center, raises blood pressure and slows the heart rate.

First aid
 
   Ingestion
Wash out mouth with water provided that person is conscious. Call a physician.
   Inhalation
Remove to fresh air. If breathing is difficult, call a physician.
   Skin
Immediate flush with copious amounts of water.
   Eyes
Immediate flush with copious amounts of water for at least 15 minutes. Separate eyelids with fingers.

Transport.