Pilocarpine hydrochloride

  • Pilocarpine muriate
  • Salagen
  • Pilovisc
  • Adsorbocarpine
  • 2(3H)-Furanone, 3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-, monohydrochloride, (3S-cis)-
  • 2(3H)-Furanone, 3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-, monohydrochloride, (3S,4R)-
Formula
C11H16N2O2.ClH
Structure
Description
odorless white to off-white crystalline powder
Uses
Miotic. Used to reduce the eye of the pupil during the treatment of glaucoma.

Registry Numbers and Inventories.
CAS
54-71-7
EC (EINECS/ELINCS)
200-212-5
RTECS
TK1450000
RTECS class
Drug; Reproductive Effector; Human Data
UN (DOT)
2811
Beilstein/Gmelin
4034491
Canada DSL/NDSL
NDSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed

Properties.
Formula
C11H16N2O2*ClH
Formula mass
244.75
Melting point, °C
202

Hazards and Protection.
Storage
Store in a cool, dry place. Store in a tightly closed container. Store protected from light.
Handling
Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood.
Protection
Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Avoid runoff into storm sewers and ditches which lead to waterways. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions.
Stability
Stable under normal shipping and handling conditions.
Incompatibilities
Strong oxidizing agents.
Decomposition
Hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide, oxides of chlorine.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. This material in sufficient quantity and reduced particle size is capable of creating a dust explosion. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.
Fire potential
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.
Hazards
Contact with metals may evolve flammable hydrogen gas.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.

Health.
Exposure effects
   Ingestion
May be fatal if swallowed. May cause irritation of the digestive tract.
   Inhalation
May be fatal if inhaled. May cause respiratory tract irritation.
   Skin
May cause skin irritation. May be harmful if absorbed through the skin.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
SPEED IS ESSENTIAL. A DOCTOR MUST BE NOTIFIED AT ONCE. Wash mouth out with water.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
   Skin
Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
2811
Response guide
Hazard class
6.1
Packing Group
I; II; III