Piroxicam

  • Feldene
  • 4-Hydroxy-2-methyl-3-(pyrid-2-yl-carbamoyl)-2H-1,2-benzothiazine 1,1-dioxide
  • 4-Hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
  • 4-Hydroxy-2-methyl-N-2-pyridinyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
Formula
C15H13N3O4S
Structure
Uses
Non-steroidal anti-inflamatory agent (NSAID) shown to be effective in the chomoprevention of colon cancer.

Registry Numbers and Inventories.
CAS
36322-90-4
EC (EINECS/ELINCS)
252-974-3
RTECS
DL0705000
RTECS class
Drug; Reproductive Effector; Human Data
UN (DOT)
2811
Merck
12,7661
Beilstein/Gmelin
627692
Beilstein Reference
6-27
Canada DSL/NDSL
DSL
Austrailia AICS
Listed
New Zealand
Listed
Korea ECL
Listed

Properties.
Formula
C15H13N3O4S
Formula mass
331.35
Melting point, °C
200 - 202
Density
1.481 g/cm3
Solubility in water
Soluble
pKa/pKb
4.50 (pKa)
Partition coefficient, pKow
0.3
Heat of fusion
21.3 kJ/mol

Hazards and Protection.
Storage
Keep tightly closed. Store at 2-8 C
Protection
Compatible chemical-resistant gloves. Chemical safety goggles.
Respirators
Government approved respirator.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable at normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Carbon monoxide, Carbon dioxide, Nitrogen oxides, Sulfur oxides.

Fire.
Fire fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Fire potential
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.
Hazards
Emits toxic fumes under fire conditions.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.
Health
2
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
Harmful if swallowed. Possible sensitizer. Target organ(s): Blood. Kidneys.
   Ingestion
Harmful if swallowed.
   Inhalation
Material may be irritating to mucous membranes and upper respiratory tract. May be harmful if inhaled.
   Skin
May cause skin irritation. May be harmful if absorbed through the skin.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
   Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.
UN number
2811
Response guide
Hazard class
6.1
Packing Group
III