Platelet activating factor

  • 2-Acetyl-1-alkyl-sn-glycero-3-phosphocholine
  • 1-O-Alkyl-2-acetyl-sn-glycero-3-phosphocholine
  • N-(Acetylmuramyl)-L-alanyl-D-isoglutamine
  • Muramyl dipeptide
Formula
C19H32N4O11
Structure
Uses
Phospholipid produced by lymphocytes, platelets and endothelial cells that induces platelet aggregation and is involved in inflammation, anaphylaxis and wound repair.

Registry Numbers and Inventories.
CAS
53678-77-6
EC (EINECS/ELINCS)
258-696-9
22 38 40 48/20/22
RTECS
MA2275260
RTECS class
Reproductive Effector
UN (DOT)
1888
Merck
12,6385
Beilstein/Gmelin
4220745
Beilstein Reference
6-04

Properties.
Formula
C19H32N4O11
Formula mass
492.48
Melting point, °C
134
pKa/pKb
4.44 (pKa)
Heat of vaporization
177.8 kJ/mol

Hazards and Protection.
Storage
Keep tightly closed. Store at -20 C
Protection
Compatible chemical-resistant gloves. Chemical safety goggles.
Respirators
Government approved respirator in nonventilated areas and/or for exposure above the TLV or PEL.
Small spills/leaks
Absorb on sand or vermiculite and place in closed containers for disposal. Ventilate area and wash spill site after material pickup is complete.
Incompatibilities
Strong oxidizing agents, Strong bases, Magnesium, Sodium, Lithium.
Decomposition
Carbon monoxide, Carbon dioxide, Phosgene gas, Chlorine.

Fire.
Fire fighting
Extinguish using Noncombustible. Use extinguishing media appropriate to surrounding fire conditions. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Fire potential
Non-Combustible
Hazards
Emits toxic fumes under fire conditions.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.
Health
2
 
Flammability
0
 
 
Reactivity
1
 

Health.
Exposure effects
Harmful. Harmful if swallowed. Irritating to eyes and skin. Limited evidence of a carcinogenic effect. Harmful: danger of serious damage to health by prolonged exposure through inhalation and if swallowed. Possible Carcinogen (US). Targ
   Ingestion
Harmful if swallowed.
   Inhalation
May be harmful if inhaled. Material may be irritating to mucous membranes and upper respiratory tract.
   Skin
Causes skin irritation. Skin absorption may occur. May be harmful if absorbed through the skin.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.
   Skin
In case of contact, immediately wash skin with soap and copious amounts of water.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.
UN number
1888
Response guide
Hazard class
6.1
Packing Group
III