Polysorbate 80

  • Sorbitan, monooleate polyoxyethylene deriv.
  • TWEEN 80
  • Polyoxyethylene 20 sorbitan oleate
  • Poly(20)oxyethylene sorbitan monooleate
  • Sorbitan, mono-(9Z)-9-octadecenoate, poly(oxy-1,2-ethanediyl) derivs.
Description
Amber-colored viscous liquid. Faint fatty odor and bitter taste.
Uses
Usp grade is used as emulsifier & dispersing agent for medicinal products designed for internal use, pharmaceutic aid (surfactant).

Registry Numbers and Inventories.
CAS
9005-65-6
EC (EINECS/ELINCS)
500-019-9
RTECS
WG2932500
RTECS class
Tumorigen; Mutagen; Reproductive Effector; Primary Irritant
Beilstein/Gmelin
NA
EPA OPP
79086
Swiss Giftliste 1
G-4122
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Melting point, °C
-21
Boiling point, °C
>100
Vapor pressure, mmHg
<1
Density
1.062 g/cm3
Solubility in water
Very soluble
Viscosity
270-430 centistokes

Hazards and Protection.
Storage
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. No special precautions indicated.
Handling
Wash thoroughly after handling. Wash hands before eating. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Clean up spills immediately, using the appropriate protective equipment. Provide ventilation.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Oxidizing agents.
Decomposition
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Fire.
Flash Point,°C
> 149
Autoignition, °C
> 180
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Containers may explode when heated. Extinguishing media: Use agent most appropriate to extinguish fire. Cool containers with flooding quantities of water until well after fire is out. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Fire potential
This chemical is probably combustible.
Hazards
Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.
Health
1
 
Flammability
1
 
 
Reactivity
0
 

Health.
Poison_Class
-
Exposure effects
Reproductive effects have been reported in animals.
   Ingestion
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. Low hazard for usual industrial handling.
   Inhalation
May cause respiratory tract irritation. Low hazard for usual industrial handling.
   Skin
May cause skin irritation.
   Eyes
May cause mild eye irritation.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Wash mouth out with water. Get medical aid if irritation or symptoms occur.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.
USCG CHRIS Code
PSM
 
HS Code
3402 13 00
 
IMO Pollution Category
III