Prednimustine

  • Chlorambucil-ester-of-prednisolone
  • Chlorambucil-prednisolone-ester
  • LEO-1031
  • NSC-134087
  • Pregna-1,4-diene-3,20-dione, 11-beta,17,21-trihydroxy-, 21-(4-(p-(bis(2-chloroethyl)amino) phenyl)butyrate)
  • Prednisolone 21-(4-(p-(bis(2-chloroethyl)amino)phenyl)butyrate)
Formula
C35H45Cl2NO6
Structure
Uses
Used as a cytostatic drug, mainly for the treatment of malignancies of lymphatic tissue.

Registry Numbers and Inventories.
CAS
29069-24-7
EC (EINECS/ELINCS)
249-410-3
RTECS
TU4153000
RTECS class
Tumorigen; Drug; Human Data
Merck
12,7900
Beilstein/Gmelin
2826967

Properties.
Formula
C35H45Cl2NO6
Formula mass
646.65
Melting point, °C
163
Boiling point, °C
792
Vapor pressure, mmHg
2E-26 (25 C)
Solubility in water
Insoluble
pKa/pKb
12.33 (pKa)
Heat of vaporization
120.7 kJ/mol

Hazards and Protection.

Fire.
Flash Point,°C
433

Health.
Exposure effects
Properties of this material have not yet been prepared. Any recommendations are of a general nature. Many chemicals cause irritation of the eyes, skin, and respiratory tract. In severe cases respiratory tract irritation can progress to ARDS/acute lung injury which may be delayed in onset for up to 24 to 72 hours in some cases Irritation or burns of the esophagus or gastrointestinal tract are also possible if caustic or irritant chemicals are ingested. ALWAYS contact your local poision control authority or medical professional for assistance.

First aid
 

Transport.