Primaquine diphosphate

  • Primachin
  • 1,4-Pentanediamine, N(sup 4)-(6-methoxy-8-quinolinyl)-, phosphate (1:2)
  • 8-((4-Amino-1-methylbutyl)amino)-6-methoxyquinoline diphosphate
  • Quinoline, 8-((4-amino-1-methylbutyl)amino)-6-methoxy-, phosphate (1:2)
Formula
C15H21N3O . 2H3PO4
Structure
Description
Orange.
Uses
antimalarial agent

Registry Numbers and Inventories.
CAS
63-45-6
EC (EINECS/ELINCS)
200-560-8
RTECS
VA9660000
RTECS class
Drug; Mutagen; Reproductive Effector
UN (DOT)
2811
Beilstein/Gmelin
3812133
Beilstein Reference
5-22-12-00127
Austrailia AICS
Listed

Properties.
Formula
C15H21N3O*2H3O4P
Formula mass
455.34
Melting point, °C
197 - 198

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Wear appropriate protective gloves, clothing and goggles.
Respirators
Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions.
Small spills/leaks
Sweep up, then place into a suitable container for disposal.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Nitrogen oxides, phosphine, carbon monoxide, carbon dioxide, nitrogen.

Fire.
Fire fighting
Extinguish using agent most appropriate for surrounding fire.
Fire potential
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.
Hazards
Contact with metals may evolve flammable hydrogen gas.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.

Health.
Exposure effects
   Ingestion
See Inhalation.
   Inhalation
TOXIC; inhalation, ingestion, or skin contact with material may cause severe injury or death. Effects of contact or inhalation may be delayed.
   Skin
Contact with molten substance may cause severe burns to skin and eyes. See Inhalation.
   Eyes
See Inhalation.

First aid
 
   Ingestion
Do NOT induce vomiting. Allow the victim to rinse his mouth and then to drink 2-4 cupfuls of water, and seek medical advice.
   Inhalation
Remove from exposure to fresh air immediately.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Immediately flush with running water for at least 20 minutes.

Transport.
UN number
2811
Response guide
Hazard class
6.1
Packing Group
I; II; III