Probucol

  • Biphenabid
  • Bisbid
  • Bisphenabid
  • 4,4'-(Isopropylidenedithio)bis[2,6-di-tert-butylphenol]
  • 4,4'-(Isopropylidenedithio)bis(2,6-tert-butylphenol)
  • Acetone, bis(3,5-di-tert-butyl-4-hydroxyphenyl) mercaptole
Formula
C31H48O2S2
Structure
Uses
Used to lower levels of cholesterol in the blood.

Registry Numbers and Inventories.
CAS
23288-49-5
EC (EINECS/ELINCS)
245-560-9
RTECS
AL3705000
RTECS class
Drug; Human Data
Merck
12,7935
Beilstein/Gmelin
2026253
Beilstein Reference
6-06
Austrailia AICS
Listed

Properties.
Formula
C31H48O2S2
Formula mass
516.85
Melting point, °C
117 118
Boiling point, °C
547
Vapor pressure, mmHg
1E-12 (25 C)
Density
1.11 g/cm3
Solubility in water
Insoluble
pKa/pKb
10.24 (pKa)
Partition coefficient, pKow
10.75
Heat of vaporization
85.7 kJ/mol

Hazards and Protection.
Storage
Keep tightly closed. Store in a cool dry place.
Protection
Compatible chemical-resistant gloves. Chemical safety goggles.
Respirators
Government approved respirator.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable at normal temperatures and pressures.
Decomposition
Carbon monoxide, Carbon dioxide, Sulfur oxides.

Fire.
Flash Point,°C
265
Fire fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Hazards
Emits toxic fumes under fire conditions.

Health.
Exposure effects
Avoid contact and inhalation. Target organ(s): Heart.
   Inhalation
Material may be irritating to mucous membranes and upper respiratory tract.
   Skin
May cause skin irritation.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.
   Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.