Procaine

  • Allocaine
  • beta-(Diethylamino)ethyl p-aminobenzoate
  • beta-Diethylaminoethyl 4-aminobenzoate
  • Diethylaminoethyl p-aminobenzoate
  • 2-(Diethylamino)ethyl p-aminobenzoate
  • 2-Diethylaminoethyl 4-aminobenzoate
Formula
C13H20N2O2
Structure
Description
Anhydrous plates, tables from ligroin or ether.
Uses
Medication.

Registry Numbers and Inventories.
CAS
59-46-1
EC (EINECS/ELINCS)
200-426-9
RTECS
DG2100000
RTECS class
Drug; Human Data
Merck
12,7937
Beilstein/Gmelin
913480
Beilstein Reference
4-14-00-01138
New Zealand
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C13H20N2O2
Formula mass
236.31
Melting point, °C
332.5 - 334
Boiling point, °C
228 - 231 (6 torr)
Density
1.17 g/cm3
Solubility in water
9.45 g/L @ 30 C
pKa/pKb
5.95 (pKb)
Partition coefficient, pKow
1.92

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability
Stable in air.
Incompatibilities
Strong oxidizing agents.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
Generalized depression of vital signs may follow a period of transient physiological stimulation. CNS effects invariably precede significant cardiovascular toxicity, except following massive iv injection.
   Ingestion
Nausea, vomiting, and depression of the gag reflex may occur.
   Inhalation
Apnea and respiratory depression may occur in patients with coma or seizures. Increased respirations are associated with milder forms of CNS stimulation. ARDS has been reported in patients with aspiration or during hypersensitivity reactions.
   Skin
Urticaria and angioedema may accompany systemic allergic reactions. Other dermatological effects include contact dermatitis, generalized burning and numbness, and pruritus. Vasodilation, with pink skin, has been reported.
   Eyes
Constriction of the pupil and tinnitus may occur.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.

Transport.