Procarbazine

  • Ibenzmethyzin
  • n-4-isopropylcarbamoylbenzyl-n'-methylhydrazine
  • n-Isopropyl-alpha-(2-methylhydrazino)-p-toluamide
  • n-(1-Methylethyl)-4
  • 4-((2-Methylhydrazino)methyl)-n-Isopropylbenzamide
  • p-(N'-Methylhydrazinomethyl)-n-Isopropylbenzamide
Formula
C12H19N3O
Structure
Uses
Medication (vet).

Registry Numbers and Inventories.
CAS
671-16-9
EC (EINECS/ELINCS)
211-582-2
RTECS
XS4550000
RTECS class
Tumorigen; Drug; Mutagen; Reproductive Effector
Merck
12,7938
Beilstein/Gmelin
958270
Japan ENCS (MITI)
Listed

Properties.
Formula
C12H19N3O
Formula mass
221.3
pKa/pKb
6.6 (pKa)
Partition coefficient, pKow
0.06

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Respiratory protection should be an adjunct to and not a substitute for engineering controls.<BR>Organic vapor acid gas canister; done in the open, an area away from drafts and traffic
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability
Stable in light, slowly oxidized in air. Hydrochloride stable @ room temperature (in presence of oxygen, oxidn is accelerated by incr temperature).
Incompatibilities
Strong oxidizing agents.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Carcinogin
I-2A, N-2, CP65
Exposure effects
Procarbazine is a weak mao inhibitor. A hypertensive reaction may occur with concurrent use of sympathomimetic agents, tricyclic antidepressants, and foods with high tyramine content; these reactions are poorly documented. with therapeutic use - paresthesias, neuropathies, dizziness, headache, insomnia, frequent nightmares, nervousness, depression, hallucinations, seizures, coma and tremors have been reported. Procarbazine is not recommended for use during pregnancy or lactation.
   Ingestion
Ausea, vomiting and diarrhea may occur.
   Inhalation
Interstitial pneumonitis occurs rarely and may be an allergic reaction during therapeutic use.
   Skin
Pruritus, hyperpigmentation, flushing, alopecia, and jaundice may be noted. Herpetic lesions may occur.
   Eyes
Nystagmus, diplopia, papilledema, photophobia and retinal hemorrhage may occur with therapeutic use.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.