Prochlorperazine

  • Capazine
  • Chlormeprazine
  • 2-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)phenothiazine
  • 2-Chloro-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine
  • 3-Chloro-10-chlorperazine
  • 3-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)phenothiazine
Formula
C20H24ClN3S
Structure
Description
Clear, pale yellow, viscous liquid.
Uses
Antiemetic, antipsychotic. In the treatment of vertigo.

Registry Numbers and Inventories.
CAS
58-38-8
EC (EINECS/ELINCS)
200-379-4
RTECS
SO2700000
RTECS class
Drug; Reproductive Effector; Human Data
Merck
12,7942
Beilstein/Gmelin
48537
Beilstein Reference
4-27-00-01307
Austrailia AICS
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C20H24ClN3S
Formula mass
373.95
Melting point, °C
220
Boiling point, °C
224 - 234 (0.5 torr)
Solubility in water
Insoluble.
Partition coefficient, pKow
4.88

Hazards and Protection.
Storage
Protect from light. Keep in a tightly closed container in a cool, dry location.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Not required for the normal use of this material.
Small spills/leaks
Use protective equipment. Absorb spill with inert material. Shove into a container for disposal.
Stability
Stable at normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
No data.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
Phenothiazines may interfere with the body's ability to thermoregulate, and cause elevated body temperature or reduced body temperature. Abnormally low blood pressure and elevated blood pressure have both been reported; abnormally low blood pressure is the more common serious effect. CNS depression, coma, agitation, extrapyramidal signs, and seizures may occur with overdose. Neuroleptic malignant syndrome has rarely occurred with therapeutic use and overdose. Most phenothiazines are rated pregnancy category C and should be used only when potential therapeutic benefit outweighs potential effects on the fetus.
   Ingestion
Gastrointestinal abnormalities, especially constipation with possible obstruction, may occur with phenothiazine overdose.
   Inhalation
Respiratory depression, pulmonary edema, and a loss of the gag reflex with possible aspiration may occur with phenothiazine overdose.
   Skin
Itching, redness, swelling, irritation.
   Eyes
Irritation.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.