- L-2-Oxothiazolidine-4-carboxylic Acid
- 4-Thiazolidinecarboxylic acid, 2-oxo-, (R)
White solid, packaged under an inert gas.
A cell-permeable, non-toxic thiazolidine procysteine antioxidant that increases intracellular glutathione levels. Reported to minimize the oxidative damage in amyloid protein precursor ( APP)-mediated cell death. Also reported as a lead for the treatment of amyotrophic lateral sclerosis (ALS). Shown to protect the liver against ethanol-induced injury in rats. Also shown to inhibit HIV-1 replication in mononuclear phagocytes and lymphocytes. Induces insulin secretion in isolated pancreatic islets through CD38 dimerization and internalization.
Registry Numbers and Inventories.
Melting point, °C
171 - 173
1.582 g/cm3 (20 C)
Solubility in water
Partition coefficient, pKow
Hazards and Protection.
Refrigerate (+4 C). Protect from moisture.
This product is stable for 2 years as supplied. Unstable in solution; reconstitute just prior to use.