Promegestone

  • Estra-4,9-dien-3-one, 17-methyl-17-(1-oxopropyl)-, (17-beta)-
  • Estra-4,9-dien-3-one, 17-alpha-methyl-17-propionyl
  • R-5020
  • RU5020
Formula
C22H30O2
Structure
Description
Colorless, odorless solid.
Uses
Used as a radioligand for the progestin receptor.

Registry Numbers and Inventories.
CAS
34184-77-5
RTECS
KG2965000
Merck
12,7969
Beilstein/Gmelin
2300926
Beilstein Reference
5-07

Properties.
Formula
C22H30O2
Formula mass
326.48
Melting point, °C
152
Vapor pressure, mmHg
1.3E-9 (25 C)
Density
1.09 g/cm3
Solubility in water
Insoluble
Partition coefficient, pKow
4.39
Heat of vaporization
75.25

Hazards and Protection.
Storage
Store in cool place. Keep contents under nitrogen.
Protection
Protective gloves, safety glasses with side-shields, lab coat.
Respirators
No personal respiratory protective equipment normally required.
Small spills/leaks
Soak up with inert absorbent material. Clean contaminated surface thoroughly. Keep in suitable and closed containers for disposal.
Stability
Stable at normal conditions.
Incompatibilities
Strong oxidizing agents.
Decomposition
Thermal decomposition can lead to release of irritating gases and vapors.

Fire.
Flash Point,°C
180
Fire fighting
Suitable extinguishing media water, dry chemical, carbon dioxide (CO2), or foam. Wear suitable protective equipment.
Combustion products
In the event of fire toxic fumes may be formed.

Health.
Exposure effects
Teratogenic. May impair fertility. Toxic by inhalation, ingestion and in contact with the skin. May cause sensitization of susceptible persons.
   Inhalation
May be irritating to mucous membranes and upper respiratory tract.

First aid
 
   Ingestion
Rinse mouth. Never give anything by mouth to an unconscious person. Obtain medical attention.
   Inhalation
Move to fresh air. Oxygen or artificial respiration if needed.
   Skin
Wash off immediately with soap and plenty of water removing all contaminated clothes and shoes.
   Eyes
Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Consult a physician.

Transport.