Registry Numbers and Inventories.
Drug; Mutagen; Reproductive Effector; Human Data; Primary Irritant
Japan ENCS (MITI)
Melting point, °C
Boiling point, °C
Vapor pressure, mmHg
1E-6 (25 C)
1.369 g/cm3 (22 C)
Solubility in water
15.6 mg/L (24 C)
65 g/s2 (25 C)
Partition coefficient, pKow
Heat of vaporization
Hazards and Protection.
The product should be stored at controlled room temperature and protected from freezing and light.
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter.
If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a strong soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
In general, promethazine HCl exhibits increasing stability with decreasing pH. Promethazine HCl turns blue on prolonged exposure to air and moisture.
Incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides.
Fires involving this compound can be controlled using a dry chemical, carbon dioxide or Halon extiguisher.
CNS depression or stimulation, extensor plantar reflexes, hyperreflexia, and dystonic reactions are commonly reported following overdose. Seizures or choreoathetosis occur less frequently. With therapeutic use - CNS depression or stimulation, encephalopathy, or dystonic reactions are commonly reported. Seizures or choreoathetosis occur less frequently.
- Stridor, wheezing, or bronchospasm may be noted. The available data suggest that use of promethazine in children less than 2 years of age may be a risk factor for SIDS or phenothiazine-associated apnea.
Stridor, wheezing, or bronchospasm may be noted. The available data suggest that use of promethazine in children less than 2 years of age may be a risk factor for sids or phenothiazine-associated apnea.
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician.
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. If symptoms (such as redness or irritation) develop, immediately transport the victim to a hospital.