- 3-Hydroxy-1-propanesulphonic acid sultone
White crystalline solid or a colorless liquid.
1,3-Propane sultone is used as chemical intermediate to introduce sulfopropyl group into molecules, & to confer water solubility & anionic character.
Registry Numbers and Inventories.
EC Index Number
Carcinogenic Category 2; Harmful
R 45 21/22
S 53 45
Tumorigen; Mutagen; Reproductive Effector; Primary Irritant
Swiss Giftliste 1
Japan ENCS (MITI)
Melting point, °C
Boiling point, °C
Vapor pressure, mmHg
0.0024 (24 C)
Vapor density (air=1)
1.3996 g/cm3 (35 C)
Solubility in water
1.4585 (20 C)
Partition coefficient, pKow
Heat of vaporization
Hazards and Protection.
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Do not ingest or inhale.
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Provide ventilation. Do not get water inside containers.
Stable under normal shipping and handling conditions. However may react slowly with water forming corrosive acid.
Strong oxidizing agents, bases.
Carbon monoxide, oxides of sulfur, carbon dioxide.
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Dusts at sufficient concentrations can form explosive mixtures with air. Extinguishing media: Use water spray, dry chemical, or carbon dioxide. Do NOT get water inside containers.
Combustible material: may burn but does not ignite readily.
When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.
When heated to decomposition propane sultone emits toxic fumes of sox.
NIOSH REL: Ca See Appendix A
G-A3, I-2B, N-2, CP65
May cause cancer in humans.
Harmful if swallowed. May cause severe gastrointestinal tract irritation with nausea, vomiting and possible burns. May cause central nervous system effects.
May cause respiratory tract irritation.
May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. Causes severe burns.
Causes severe eye irritation and possible burns.
Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Get medical aid immediately. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Discard contaminated clothing in a manner which limits further exposure.
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Do NOT allow victim to rub or keep eyes closed.
I; II; III
USCG CHRIS Code