ß-Propiolactone

  • 2-Oxetanone
  • Propanolide
  • 1,3-Propiolactone
  • Hydroacrylic acid
  • 3-Hydroxy-ß-lactone
  • Propiolactone
Formula
C3H4O2
Structure
Description
A colorless liquid with a slightly sweetish, pungent odor.
Uses
Versatile intermediate in organic synthesis, disinfectant.

Registry Numbers and Inventories.
CAS
57-57-8
EC (EINECS/ELINCS)
200-340-1
EC Index Number
606-031-00-1
EC Class
Carcinogenic Category 2; Very toxic; Irritant
RTECS
RQ7350000
RTECS class
Agricultural Chemical and Pesticide; Tumorigen; Mutagen
UN (DOT)
2810
Merck
12,8005
Beilstein/Gmelin
1360
Beilstein Reference
5-17-09-00003
EPA OPP
10901
Swiss Giftliste 1
G-2788
Canada DSL/NDSL
NDSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C3H4O2
Formula mass
72.06
Melting point, °C
-31.2
Boiling point, °C
155
Decomposition point, °C
162
Vapor pressure, mmHg
2.2 (25 C)
Vapor density (air=1)
2.5
Critical temperature
389
Critical pressure
53.1
Density
1.145 g/cm3 (20 C)
Solubility in water
370 g/L (25 C)
Surface tension
22 g/s2 (20 C)
Refractive index
1.4138 (20 C)
Dipole moment
4.18 D
Partition coefficient, pKow
0.462
Heat of fusion
9.4 kJ/mol
Heat of vaporization
39.9 kJ/mol
Heat of combustion
-1410 kJ/mol

Hazards and Protection.
Storage
Keep away from sources of ignition. Store in a tightly closed container. Deep freeze (below -20 C). Store protected from light. Store under argon.
B3 D2A
Handling
Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood.
Protection
Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Avoid runoff into storm sewers and ditches which lead to waterways. Neutralize spill with sodium bicarbonate. Cover with sand, dry lime or soda ash and place in a closed container for disposal. Remove all sources of ignition. Provide ventilation.
Stability
Stable when stored at +5 C in glass containers.
Incompatibilities
Strong oxidizing agents, strong bases, strong acids, acetates, halogens, thiocyanates, 2-aminoethanol, ammonium hydroxide, aniline, chlorosulfonic acid, ethylene diamine, ethyleneimine, hydrochloric acid, hydrofluoric acid, nitric acid, oleum, pyridine, sodium hydroxide, sulfuric acid.
Decomposition
Carbon monoxide, carbon dioxide.

Fire.
Flash Point,°C
74
Upper exp. limit, %
25.1
Lower exp. limit, %
2.9
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Will burn if involved in a fire. Combustible Liquid. Extinguishing media: Use water spray to cool fire-exposed containers. In case of fire use water spray, dry chemical, carbon dioxide, or chemical foam.
Fire potential
Moderately flammable. Combustion with moderate heating.
Hazards
Containers may explode. When heated to decomposition, it emits acrid smoke and fumes. Stable when stored at 41F. Avoid storing in areas of exposure to the direct rays of the sun and in areas of high fire hazard. Tends to polymerize on storage. Avoid elevated temperatures.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.
Health
3
 
Flammability
2
 
 
Reactivity
3
 

Health.
Exposure limit(s)
TLV: 0.5 ppm; 1.5 mg/m3 A3 (ACGIH 1997). OSHA PEL: 1910.1013 See Appendix B NIOSH REL: Ca See Appendix A NIOSH IDLH: Potential occupational carcinogen N.D
Carcinogin
O, G-A3, I-2B, N-2, CP65
Poison_Class
1*
Exposure effects
May cause cancer in humans. Animal studies have reported the development of tumors.
   Ingestion
May be harmful if swallowed. May cause irritation of the digestive tract and possible burns. May cause nausea, vomiting, headache, cramps, chills and drowsiness.
   Inhalation
Inhalation may be fatal as a result of spasm, inflammation, edema of the larynx and bronchi, chemical pneumonitis and pulmonary edema. Toxic if inhaled. May cause burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting. Inhalation may cause sore throat, shortness of breath, labored breathing, coughing, and pulmonary edema.
   Skin
May be harmful if absorbed through the skin. Causes irritation with burning pain, scaling, itching and redness. May cause erythema and blistering.
   Eyes
May cause conjunctivitis. Causes redness and pain. Causes eye irritation and burns. May cause permanent corneal opacification.

First aid
 
   Ingestion
Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
   Skin
Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
2810
Response guide
Hazard class
6.1
Packing Group
I; II; III
 
USCG CHRIS Code
PLT
 
IMO Chemical Code
17
IMO Pollution Category
D
IMO Hazard code
S