Propiomazine

  • Propionylpromethazine
  • 10-(2-Dimethylaminopropyl)-2-propionylphenothiazine
  • 10-Dimethylaminoisopropyl-2-propionylphenothiazine
  • 3-Propionyl-10-dimethylaminoisopropylphenothiazine
  • 2-Propionyl-10-(2-(dimethylamino)propyl)phenothiazine
Formula
C20H24N2OS
Structure
Uses
Medication.

Registry Numbers and Inventories.
CAS
362-29-8
EC (EINECS/ELINCS)
206-646-1
Merck
12,8007
Beilstein/Gmelin
39712
Beilstein Reference
4-27-00-02922

Properties.
Formula
C20H24N2OS
Formula mass
340.49
Boiling point, °C
230 (0.5 torr)
Solubility in water
Insoluble
pKa/pKb
5.02 (pKb)

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability
No data.
Incompatibilities
Strong oxidizing agents.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
Phenothiazines may interfere with the body's ability to thermoregulate, and cause elevated body temperature or reduced body temperature. Abnormally low blood pressure and elevated blood pressure have both been reported; abnormally low blood pressure is the more common serious effect. CNS depression, coma, agitation, extrapyramidal signs, and seizures may occur with overdose. Neuroleptic malignant syndrome has rarely occurred with therapeutic use and overdose. Most phenothiazines are rated pregnancy category C and should be used only when potential therapeutic benefit outweighs potential effects on the fetus.
   Ingestion
Gastrointestinal abnormalities, especially constipation with possible obstruction, may occur with phenothiazine overdose.
   Inhalation
Respiratory depression, pulmonary edema, and a loss of the gag reflex with possible aspiration may occur with phenothiazine overdose.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.