Propionic anhydride

  • Propanoic acid anhydride
  • Methylacetic anhydride
Formula
(CH3CH2CO)2O
Structure
Description
Clear, colorless liquid with a strong, rancid odor.
Uses
Esterifying agent for certain perfume oils, fats, oils, and especially cellulose. In the production of alkylated resins, dyestuffs and drugs. Has been used as a dehydrating agent in some sulfonations and nitrations.

Registry Numbers and Inventories.
CAS
123-62-6
EC (EINECS/ELINCS)
204-638-2
EC Index Number
607-010-00-X
EC Class
Corrosive
RTECS
UF9100000
RTECS class
Primary Irritant
UN (DOT)
2496
Merck
12,8011
Beilstein/Gmelin
507066
Beilstein Reference
4-02-00-00722
EPA OPP
77704
Swiss Giftliste 1
G-4823
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C6H10O3
Formula mass
130.14
Melting point, °C
-45
Boiling point, °C
167
Vapor pressure, mmHg
1.6 (25 C)
Vapor density (air=1)
4.5
Critical temperature
349
Critical pressure
33
Density
1.0343 g/cm3 (0 C)
Solubility in water
Reacts.
Viscosity
1.144 cp @ 20C
Surface tension
30.86 g/s2 (15 C)
Refractive index
1.4041 (17 C)
Dielectric constant
18.3 (16 C)
Partition coefficient, pKow
0.58
Heat of vaporization
40.5 kJ/mol
Heat of combustion
-2800 kJ/mol

Hazards and Protection.
Storage
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Do not store near combustible materials. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
B3 E
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Do not ingest or inhale. Do not allow contact with water. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Use water spray to disperse the gas/vapor. Remove all sources of ignition. A vapor suppressing foam may be used to reduce vapors. Do not get water on spilled substances or inside containers.
Disposal code
4
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Oxidizing agents, alcohols, alkalies, water.
Decomposition
Carbon monoxide, carbon dioxide.

Fire.
Flash Point,°C
74
Autoignition, °C
285
Upper exp. limit, %
11.9
Lower exp. limit, %
1.3
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Use water spray to cool fire-exposed containers. Water may be ineffective. Do NOT get water inside containers. For large fires, use water spray, fog or alcohol-resistant foam. Do NOT use straight streams of water. For small fires, use carbon dioxide, dry chemical, dry sand, or alcohol-resistant foam. Cool containers with flooding quantities of water until well after fire is out.
Fire potential
May burn but does not ignite readily.
Hazards
Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.
Combustion products
Fire will produce irritating, corrosive and/or toxic gases.
Health
3
 
Flammability
2
 
 
Reactivity
1
 

Health.
Poison_Class
4
Exposure effects
Abnormal neuropsychologic function has been reported following hydrochloric acid exposure from a leaking tanker truck.
   Ingestion
May cause severe gastrointestinal tract irritation with nausea, vomiting and possible burns. Aspiration of material into the lungs may cause chemical pneumonitis, which may be fatal.
   Inhalation
Causes chemical burns to the respiratory tract.
   Skin
Causes skin burns.
   Eyes
Causes eye burns. Vapors may cause eye irritation.

First aid
 
   Ingestion
Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen.
   Skin
Get medical aid immediately. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Do NOT allow victim to rub or keep eyes closed.

Transport.
UN number
2496
Response guide
Hazard class
8
Packing Group
III
 
USCG CHRIS Code
PAH
 
11 Organic anhydrides
HS Code
2915 90 80
 
Std. Transport #
4931449
 
IMO Chemical Code
17
IMO Pollution Category
C
IMO Hazard code
S/P