Propofol

  • Recofol
  • Disoprivan
  • Diprofol
  • 2,6-Diisopropylphenol
  • 2,6-Bis(isopropyl)phenol
  • 2,6-Bis(1-methylethyl)phenol
Formula
C12H18O
Structure
Description
Yellow-tan liquid.
Uses
An intravenous sedative-hypnotic agent

Registry Numbers and Inventories.
CAS
2078-54-8
EC (EINECS/ELINCS)
218-206-6
R 22 36/38
S 26 36/37/39
RTECS
SL0810000
RTECS class
Drug; Reproductive Effector; Human Data
UN (DOT)
2810
Merck
12,8020
Beilstein/Gmelin
1866484
Beilstein Reference
4-06-00-03435
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C12H18O
Formula mass
178.27
Melting point, °C
18
Boiling point, °C
256
Vapor pressure, mmHg
0.01 (25 C)
Density
1.032 g/cm3
Solubility in water
Insoluble
Refractive index
1.5134 (20 C)
pKa/pKb
11.00 (pKa)
Partition coefficient, pKow
4.16
Heat of vaporization
51.3 kJ/mol

Hazards and Protection.
Storage
Store in a cool, dry place. Store in a tightly closed container. Keep under an argon blanket. Refrigerator (approx 4 C).
Handling
Avoid breathing dust, vapor, mist, or gas. Avoid contact with eyes, skin, and clothing. Use only in a chemical fume hood.
Protection
Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Oxidizing agents, bases, acid chlorides, acid anhydrides.
Decomposition
Carbon monoxide, carbon dioxide.

Fire.
Flash Point,°C
107
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.

Health.
Exposure effects
   Ingestion
Harmful if swallowed. May cause irritation of the digestive tract.
   Inhalation
Dust is irritating to the respiratory tract. The toxicological properties of this substance have not been fully investigated.
   Skin
Causes skin irritation.
   Eyes
Causes eye irritation.

First aid
 
   Ingestion
Get medical aid. Wash mouth out with water.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.
UN number
2810
Response guide
20. Alcohols. Glycols