Propyl thiouracil

  • 2,3-Dihydro-6-propyl-2-thioxo-4(1h)pyrimidinone
  • 2-Mercapto-4-hydroxy-6-n-propylpyrimidine
  • 2-Mercapto-6-propylpyrimid-4-one
  • Procasil
  • Propacil
  • Propycil
Formula
C7H10N2OS
Structure
Description
Odorless white crystalline powder of starch-like appearance. Bitter taste. Saturated solution is neutral or slightly acid to litmus.
Uses
Medication.

Registry Numbers and Inventories.
CAS
51-52-5
EC (EINECS/ELINCS)
200-103-2
EC Class
harmful
RTECS
YR1400000
RTECS class
Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data
Merck
12,8054
Beilstein/Gmelin
130039
Beilstein Reference
5-24-07-00257
Canada DSL/NDSL
NDSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C7H10N2OS
Formula mass
170.23
Melting point, °C
215 - 218
Boiling point, °C
448
Vapor pressure, mmHg
0.54 (25 C)
Solubility in water
Slightly soluble
pKa/pKb
7.63 (pKa)
Partition coefficient, pKow
1.37

Hazards and Protection.
Storage
Store in a cool, dry place. Keep container closed when not in use. Hormones and antibiotics room.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Protection
Eyes: Wear chemical goggles. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Incompatible with strong oxidizing agents, strong acids and strong bases Reacts with sulfhydryl-oxidizing agents.
Decomposition
Irritating and toxic fumes and gases.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire.

Health.
Carcinogin
I-2B, N-2, CP65
Exposure effects
   Ingestion
See inhalation.
   Inhalation
Symptoms of exposure to this compound include recurrent painful skin lesions, fatigue, migratory polyanthralgias of hands and knees, palpable spleen, splenomegaly, amenorrhea, low-grade fever, gingivostomatitis, weakness, weight loss, dark red-brown colored urine, necrotizing vasculitis, leukopenia, cutaneous vasculitis, nasal congestion, enlarged thyroid, necrotic ulcerations on the lower extremities, bloody nasal discharge and cough.
   Skin
Skin rashes may occur secondary to hematologic toxicity during chronic therapy.
   Eyes
See inhalation

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid immediately.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Remove contaminated clothing and shoes.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
HS Code
2933 59 95