Prostaglandin E1

  • Alprostadil
  • Prost-13-en-1-oic acid
  • Cyclopentaneheptanoic acid, 3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxo-, l
  • SEPA-prostaglandin E1
  • Prostin VR Pediatric
  • Prost-13-en-1-oic acid, 11,15-dihydroxy-9-oxo-, (11a,13E,15S)-
Formula
C20H34O5
Structure
Description
White solid.
Uses
Dilatation of ductus arteriosus in infants with ductal dependent congenital heart defects.

Registry Numbers and Inventories.
CAS
745-65-3
EC (EINECS/ELINCS)
212-017-2
RTECS
GY4569800
RTECS class
Mutagen; Reproductive Effector; Human Data; Hormone
Merck
12,8063
Beilstein/Gmelin
1890728

Properties.
Formula
C20H34O5
Formula mass
354.48
Melting point, °C
115-116

Hazards and Protection.
Storage
Store in a cool, dry place. Keep container closed when not in use.
Handling
Wash thoroughly after handling. Use only in a well ventilated area. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Carbon monoxide, carbon dioxide.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire, use water fog, dry chemical, carbon dioxide, or regular foam.

Health.
Exposure effects
   Ingestion
Harmful if swallowed. Causes gastrointestinal tract irritation.
   Inhalation
The toxicological properties of this substance have not been fully investigated.
   Skin
No information regarding skin irritation and other potential effects was found.
   Eyes
No information regarding eye irritation and other potential effects was found.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
   Skin
Get medical aid immediately. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.