Prostaglandin E2

  • Cerviprost
  • Dinoprostone
  • Glandin
  • Minprositin E2
  • 7-(3-HydroxyProsta-5,13-dien-1-oic acid, (5Z,11-alpha,13E,15S)-11,15-dihydroxy-9-oxo-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-5-heptenoic acid
  • 7-(3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-5-heptenoic acid
Formula
C20H32O5
Structure
Description
White crystals.
Uses
Induction of labor.

Registry Numbers and Inventories.
CAS
363-24-6
EC (EINECS/ELINCS)
206-656-6
RTECS
UK8000000
RTECS class
Drug; Mutagen; Reproductive Effector; Human Data; Hormone
Merck
12,8064
Beilstein/Gmelin
2224724

Properties.
Formula
C20H32O5
Formula mass
352.47
Melting point, °C
70
Density
1.114 g/cm3
Solubility in water
Slightly soluble
pKa/pKb
4.76 (pKa)

Hazards and Protection.
Storage
Keep container closed when not in use. Deep freeze (below -20 C). Store protected from light. Store with dessicant.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation. Store protected from light. Use only in a chemical fume hood.
Protection
Eyes: Wear safety glasses and chemical goggles if splashing is possible. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.
Stability
Stable under normal temperatures and pressures. Light sensitive.
Incompatibilities
Acids, bases.
Decomposition
Carbon monoxide, carbon dioxide, acrid smoke and fumes.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use carbon dioxide, dry chemical powder or appropriate foam.
Health
1
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
Chronic exposure may cause reproductive disorders and teratogenic effects. May cause termination of pregnancy.
   Ingestion
Causes gastrointestinal irritation with nausea, vomiting and diarrhea. May be harmful if swallowed. Other effects include headache, flushing, shivering and dizziness.
   Inhalation
The toxicological properties of this substance have not been fully investigated. May cause irritation of the mucous membranes.
   Skin
May cause skin irritation. The toxicological properties of this material have not been fully investigated.
   Eyes
May cause eye irritation. The toxicological properties of this material have not been fully investigated.

First aid
 
   Ingestion
Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if symptoms occur.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. If irritation develops, get medical aid.

Transport.