Proxyphylline

  • 7-(b-Hydroxypropyl)theophylline
  • 1,3-Dimethyl-7-(2-hydroxypropyl)xanthine
  • (1,3-Dimethyl-7-[2-hydroxypropyl]-2,6-dioxopurine)
  • 2,6-Dioxo-3,7-dihydro-7-(2-hydroxypropyl)-1,3-dimethylpurine
Formula
C10H14N4O3
Structure
Uses
Bronchodilator.

Registry Numbers and Inventories.
CAS
603-00-9
EC (EINECS/ELINCS)
210-028-7
RTECS
XH5907500
RTECS class
Drug
Merck
12,8092
Beilstein/Gmelin
262773
Beilstein Reference
5-26-14-00049
Austrailia AICS
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C10H14N4O3
Formula mass
238.25
Melting point, °C
135 - 136
Boiling point, °C
487
Vapor pressure, mmHg
3E-10 (25 C)
Solubility in water
601 g/L (25 C)
pKa/pKb
12.97 (pKa)
Heat of vaporization
79.3 kJ/mol

Hazards and Protection.
Storage
Keep tightly closed.
Protection
Compatible chemical-resistant gloves. Chemical safety goggles.
Respirators
Government approved respirator.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable at normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Carbon monoxide, Carbon dioxide,

Fire.
Flash Point,°C
249
Fire fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Hazards
Emits toxic fumes under fire conditions.
Health
2
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
Harmful if swallowed. Target organ(s): Heart. Nerves.
   Ingestion
Harmful if swallowed.
   Inhalation
Material may be irritating to mucous membranes and upper respiratory tract. May be harmful if inhaled.
   Skin
May cause skin irritation. May be harmful if absorbed through the skin.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
   Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.